Concepedia

Peripheral Replication

Peripheral Replication is a mechanism in prion biology whereby prions propagate outside the central nervous system, particularly in lymphoid tissues, prior to neuroinvasion, distinguishing it from direct neural replication by enabling early amplification and dissemination of infectious prion proteins.

43

Publications

3.3K

Citations

194

Authors

91

Institutions

Publications per year

2017–2026

2

Parents

Publications

43

Impaired Prion Replication in Spleens of Mice Lacking Functional Follicular Dendritic Cells

Fabio Montrasio, Rico Frigg, Markus Glatzel et al. · Science · 2000 · 355 citations

, , +16

Presymptomatic Detection of Prions in Blood

Paula Saá, Joaquı́n Castilla, Claudio Soto · Science · 2006 · 233 citations

, , +15

Pathogenesis of mouse scrapie: Dynamics of agent replication in spleen, spinal cord and brain after infection by different routes

R.H. Kimberlin, Carol Walker · Journal of Comparative Pathology · 1979 · 215 citations

, , +17

Infected splenic dendritic cells are sufficient for prion transmission to the CNS in mouse scrapie

Pièrre Aucouturier, Frédéric Geissmann, Diane Damotte et al. · Journal of Clinical Investigation · 2001 · 161 citations

, , +17

Infected splenic dendritic cells are sufficient for prion transmission to the CNS in mouse scrapie

Pièrre Aucouturier, Frédéric Geissmann, Diane Damotte et al. · Journal of Clinical Investigation · 2001 · 153 citations · Full text

, , +17

1–5 of 43

Authors

194

  1. NA
    Neil A. Mabbott

    University of Edinburgh, United Kingdom

    7 publications · 381 citations

    7

    h-index

  2. RK
    R.H. Kimberlin

    Newbury College, United States

    6 publications · 586 citations

    6

    h-index

  3. AA
    Adriano Aguzzi

    University Hospital of Zurich, Switzerland

    5 publications · 614 citations

    5

    h-index

  4. CW
    Carol Walker

    University of Liverpool, United Kingdom

    5 publications · 544 citations

    5

    h-index

  5. CW
    Charles Weissmann

    University of Zurich, Switzerland

    4 publications · 545 citations

    4

    h-index

1–5 of 194

Institutions

91

  1. Inserm

    Paris, France

    7 h-index

    17 publications

    1.8K citations

  2. University of Edinburgh

    Edinburgh, United Kingdom

    6 h-index

    18 publications

    808 citations

  3. Roslin Institute

    Dalkeith, United Kingdom

    6 h-index

    17 publications

    793 citations

  4. Centre National de la Recherche Scientifique

    Paris, France

    4 h-index

    9 publications

    877 citations

  5. Newbury College

    Brookline, United States

    4 h-index

    7 publications

    901 citations

  6. University of Zurich

    Zurich, Switzerland

    4 h-index

    26 publications

    3.5K citations

  7. Institut Pasteur

    Paris, France

    3 h-index

    3 publications

    110 citations

  8. École Nationale Vétérinaire de Toulouse

    Toulouse, France

    2 h-index

    2 publications

    110 citations

1–8 of 91

Venues

  1. Journal of Virology

    JVI · 11 publications · 922 citations

    10

    h-index

  2. Journal of General Virology

    4 publications · 272 citations

    4

    h-index

  3. Nature

    2 publications · 180 citations

    2

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 2 publications · 177 citations

    2

    h-index

  5. Journal of Clinical Investigation

    JCI · 2 publications · 314 citations

    2

    h-index

1–5