Concepedia

Peptide Loading Complex

The Peptide Loading Complex is a multiprotein complex in the endoplasmic reticulum that functions as a molecular machinery responsible for facilitating the loading of antigenic peptides onto major histocompatibility complex class I molecules, thereby distinguishing it from other components of the antigen processing and presentation pathway by its specific role in peptide optimization and MHC I stabilization.

94

Publications

6.8K

Citations

393

Authors

147

Institutions

Publications per year

2017–2026

16

Parents

Publications

94

Roles for Calreticulin and a Novel Glycoprotein, Tapasin, in the Interaction of MHC Class I Molecules with TAP

Bhanu Sadasivan, Bodo Ortmann, Thomas A. Spies et al. · Immunity · 1996 · 695 citations · Full text

, , +17

Structure of the human MHC-I peptide-loading complex

Andreas Blees, Dovile Januliene, Tommy Hofmann et al. · Nature · 2017 · 385 citations

, , +12

Early phagosomes in dendritic cells form a cellular compartment sufficient for cross presentation of exogenous antigens

Anne L. Ackerman, Christoph Kyritsis, Robert Tampé et al. · Proceedings of the National Academy of Sciences · 2003 · 373 citations · Full text

, , +15

Mice Lacking H2-M Complexes, Enigmatic Elements of the MHC Class II Peptide-Loading Pathway

Tôru Miyazaki, Paula Wolf, Sylvie Tourne et al. · Cell · 1996 · 330 citations · Full text

, , +15

Insights into MHC Class I Peptide Loading from the Structure of the Tapasin-ERp57 Thiol Oxidoreductase Heterodimer

Gang Dong, Pamela A. Wearsch, David R. Peaper et al. · Immunity · 2009 · 291 citations · Full text

, , +13

1–5 of 94

Authors

393

  1. PC
    Peter Cresswell

    Yale University, United States

    14 publications · 1.5K citations

    14

    h-index

  2. RT
    Robert Tampé

    Goethe University Frankfurt, Germany

    14 publications · 1.2K citations

    14

    h-index

  3. TH
    Ted H. Hansen

    Washington University in St. Louis, United States

    7 publications · 424 citations

    7

    h-index

  4. LL
    Lonnie Lybarger

    Washington University in St. Louis, United States

    7 publications · 414 citations

    7

    h-index

  5. RM
    Ralf M. Leonhardt

    Yale University, United States

    7 publications · 340 citations

    7

    h-index

1–5 of 393

Institutions

147

  1. Yale University

    New Haven, United States

    19 h-index

    53 publications

    8.7K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    16 h-index

    44 publications

    7.7K citations

  3. Goethe University Frankfurt

    Frankfurt am Main, Germany

    14 h-index

    57 publications

    4.8K citations

  4. Washington University in St. Louis

    St Louis, United States

    8 h-index

    30 publications

    2.1K citations

  5. National Institutes of Health

    Bethesda, United States

    5 h-index

    24 publications

    1.7K citations

  6. University of Toronto

    Toronto, Canada

    5 h-index

    14 publications

    1.1K citations

  7. University of Dundee

    Dundee, United Kingdom

    4 h-index

    10 publications

    261 citations

  8. Leiden University Medical Center

    Leiden, The Netherlands

    4 h-index

    14 publications

    851 citations

1–8 of 147

Venues

  1. The Journal of Immunology

    JI · 19 publications · 1.1K citations

    18

    h-index

  2. Journal of Biological Chemistry

    JBC · 14 publications · 684 citations

    13

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 7 publications · 849 citations

    7

    h-index

  4. International Immunology

    5 publications · 145 citations

    5

    h-index

  5. Immunity

    4 publications · 1.2K citations

    4

    h-index

1–5