Concepedia

Penitrem Biosynthesis

Penitrem Biosynthesis is a fungal secondary metabolite biosynthetic pathway that specifically produces indole-diterpene alkaloid toxins, characterized by the enzymatic assembly and modification of a geranylgeranyl diphosphate and tryptophan-derived precursor into penitrem A and related analogs via a series of prenyltransferase, cytochrome P450, and methyltransferase-catalyzed reactions.

31

Publications

1K

Citations

98

Authors

27

Institutions

Publications per year

2017–2026

1

Parents

Publications

31

Reconstitution of Biosynthetic Machinery for the Synthesis of the Highly Elaborated Indole Diterpene Penitrem

Chengwei Liu, Koichi Tagami, Atsushi Minami et al. · Angewandte Chemie International Edition · 2015 · 118 citations

, , +16

Tremorgenic Indole Alkaloids. The Total Synthesis of (−)-Penitrem D

Amos B. Smith, Naoki Kanoh, Haruaki Ishiyama et al. · Journal of the American Chemical Society · 2003 · 80 citations

, , +14

Tremorgenic mycotoxins from Penicillium crustosum. Biosynthesis of penitrem A

Amelia E. de Jesus, Charles P. Gorst‐Allman, Pieter S. Steyn et al. · Journal of the Chemical Society Perkin Transactions 1 · 1983 · 77 citations

, , +14

Structure and biosynthesis of the penitrems A–F, six novel tremorgenic mycotoxins from Penicillium crustosum

Amelia E. de Jesus, Pieter S. Steyn, Fanie R. van Heerden et al. · Journal of the Chemical Society Chemical Communications · 1981 · 57 citations

, , +16

Molecular Cloning and Functional Analysis of Gene Clusters for the Biosynthesis of Indole-Diterpenes in Penicillium crustosum and P. janthinellum

Matthew J. Nicholson, Carla J. Eaton, Cornelia Stärkel et al. · Toxins · 2015 · 42 citations · Full text

, , +17

1–5 of 31

Authors

98

  1. PG
    Peter G. Mantle

    Imperial College London, United Kingdom

    6 publications · 141 citations

    6

    h-index

  2. AB
    Amos B. Smith

    University of Pennsylvania, United States

    4 publications · 182 citations

    4

    h-index

  3. SN
    Shōichi Nakajima

    Hoshi University, Japan

    3 publications · 81 citations

    3

    h-index

  4. RV
    Robert Vleggaar

    University of Pretoria, South Africa

    3 publications · 144 citations

    3

    h-index

  5. KK
    Ken‐ichi Kawai

    Hoshi University, Japan

    3 publications · 81 citations

    3

    h-index

1–5 of 98

Institutions

27

  1. Hokkaido University

    Sapporo, Japan

    3 h-index

    13 publications

    797 citations

  2. Monell Chemical Senses Center

    Philadelphia, United States

    3 h-index

    16 publications

    924 citations

  3. Hoshi University

    Tokyo, Japan

    2 h-index

    9 publications

    231 citations

  4. Norwegian Veterinary Institute

    Oslo, Norway

    2 h-index

    4 publications

    126 citations

  5. National Institute of Infectious Diseases

    Tokyo, Japan

    2 h-index

    2 publications

    142 citations

  6. Technical University of Denmark

    Kongens Lyngby, Denmark

    2 h-index

    2 publications

    142 citations

  7. Tohoku University

    Sendai, Japan

    2 h-index

    2 publications

    142 citations

  8. Kazusa DNA Research Institute

    Kisarazu, Japan

    2 h-index

    2 publications

    142 citations

1–8 of 27

Venues

  1. 4

    h-index

  2. 2

    h-index

  3. Phytochemistry

    2 publications · 74 citations

    2

    h-index

  4. Microbiology

    2 publications · 41 citations

    2

    h-index

  5. Applied and Environmental Microbiology

    AEM · 2 publications · 57 citations

    2

    h-index

1–5