Concepedia

Pathogenic Variant Correction

Pathogenic Variant Correction is a genome editing strategy that specifically targets and rectifies disease-causing genetic alterations in situ to restore normal gene function.

53

Publications

4.8K

Citations

573

Authors

178

Institutions

Publications per year

2017–2026

42

Variants

Pathogenic Variant Repair

Parents

Publications

53

Correction of a pathogenic gene mutation in human embryos

Hong Ma, Nuria Martí‐Gutiérrez, Sang-Wook Park et al. · Nature · 2017 · 951 citations

, , +12

Predictable and precise template-free CRISPR editing of pathogenic variants

Max W. Shen, Mandana Arbab, Jonathan Y. Hsu et al. · Nature · 2018 · 630 citations · Full text

, , +14

Site-specific gene correction of a point mutation in human iPS cells derived from an adult patient with sickle cell disease

Jizhong Zou, Prashant Mali, Xiaosong Huang et al. · Blood · 2011 · 296 citations · Full text

, , +16

Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice

Pengpeng Liu, Shun‐Qing Liang, Chunwei Zheng et al. · Nature Communications · 2021 · 275 citations · Full text

, , +15

Functional Genetic Variants Revealed by Massively Parallel Precise Genome Editing

Eilon Sharon, Shi-An A. Chen, Neil M. Khosla et al. · Cell · 2018 · 253 citations · Full text

, , +11

1–5 of 53

Authors

573

  1. DR
    David R. Liu

    Harvard University, United States

    3 publications · 854 citations

    3

    h-index

  2. SA
    Scot A. Wolfe

    University of Massachusetts Chan Medical School, United States

    3 publications · 372 citations

    3

    h-index

  3. JC
    Juan Carlos Izpisúa Belmonte

    Salk Institute for Biological Studies, United States

    3 publications · 1.3K citations

    3

    h-index

  4. KS
    Keiichiro Suzuki

    The University of Osaka, Japan

    3 publications · 1.3K citations

    3

    h-index

  5. ML
    Mo Li

    Peking University, China

    2 publications · 391 citations

    2

    h-index

1–5 of 573

Institutions

178

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    5 h-index

    15 publications

    3.2K citations

  2. Harvard University

    Cambridge, United States

    4 h-index

    42 publications

    8.3K citations

  3. University of Michigan

    Ann Arbor, United States

    4 h-index

    14 publications

    799 citations

  4. Broad Institute

    Cambridge, United States

    4 h-index

    24 publications

    4.1K citations

  5. University of Oxford

    Oxford, United Kingdom

    3 h-index

    13 publications

    1.1K citations

  6. Massachusetts General Hospital

    Boston, United States

    3 h-index

    6 publications

    778 citations

  7. Sapienza University of Rome

    Rome, Italy

    3 h-index

    9 publications

    345 citations

  8. University of Massachusetts Chan Medical School

    Worcester, United States

    3 h-index

    28 publications

    4K citations

1–8 of 178

Venues

  1. Molecular Therapy

    4 publications · 252 citations

    4

    h-index

  2. Cell stem cell

    3 publications · 444 citations

    3

    h-index

  3. bioRxiv (Cold Spring Harbor Laboratory)

    Repository · 3 publications · 71 citations

    3

    h-index

  4. Nature

    3 publications · 1.6K citations

    3

    h-index

  5. Nature Genetics

    2 publications · 154 citations

    2

    h-index

1–5