Patch-clamp Electrophysiology

Patch-Clamp Electrophysiology is a high-resolution electrophysiological technique used to measure ionic currents across individual ion channels in a cell membrane by forming a tight-seal micropipette attachment to a localized membrane patch, thereby enabling the investigation of single-channel or whole-cell conductance properties under controlled voltage or current conditions.

1.6K

Publications

120.5K

Citations

4.4K

Authors

Institutions

Publications per year

2017–2026

Variants

Patch Clamp Electrophysiology

Parents

Ion Channel Biophysics

Children

Cell-attached Patch ClampCurrent-clamp RecordingInside-out Patch ClampIon Channel ActivationIon Channel InactivationIon Channel SelectivityLeak CurrentsLigand-gated Ion ChannelsLoose Patch ClampMacroscopic Current Recording

Publications

1.6K

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

Owen P. Hamill, Alain Marty, Erwin Neher et al. · Pflügers Archiv - European Journal of Physiology · 1981 · 18.5K citations

Natural Sciences, Biophysics, Cell Biology +16

Muscarinic activation of ionic currents measured by a new whole-cell recording method.

R Horn, Alain Marty · The Journal of General Physiology · 1988 · 1.8K citations · Full text

Medicine, Pharmacology, Physiology +17

A thin slice preparation for patch clamp recordings from neurones of the mammalian central nervous system

Frances A. Edwards, Arthur Konnerth, Bert Sakmann et al. · Pflügers Archiv - European Journal of Physiology · 1989 · 1.3K citations · Full text

Life Sciences, Neurobiology, Neuroscience +16

[6] Correction for liquid junction potentials in patch clamp experiments

Erwin Neher · Methods in enzymology on CD-ROM/Methods in enzymology · 1992 · 1.1K citations

Natural Sciences, Electrical Engineering, Cell Junctions +7

Sodium and calcium channels in bovine chromaffin cells

E M Fenwick, Alain Marty, Erwin Neher · The Journal of Physiology · 1982 · 968 citations

Natural Sciences, Biophysics, Physiology +17

1–5 of 1.6K

Authors

4.4K

NF
Niels Fertig
Nanion (Germany), Germany
22 publications · 1.3K citations
18
h-index
EN
Erwin Neher
Max Planck Institute for Biophysical Chemistry, Germany
16 publications · 23.7K citations
15
h-index
TB
T. B. Bolton
St George's, University of London, United Kingdom
15 publications · 1.6K citations
15
h-index
FJ
Fred J. Sigworth
Yale University, United States
14 publications · 19.3K citations
14
h-index
AN
Akinori Noma
Kyoto University, Japan
13 publications · 867 citations
12
h-index

1–5 of 4.4K

Institutions

1–8 of 1K

Venues

The Journal of Physiology
202 publications · 19.2K citations
77
h-index
Pflügers Archiv - European Journal of Physiology
96 publications · 26.4K citations
40
h-index
American Journal of Physiology-Cell Physiology
70 publications · 4.5K citations
40
h-index
Biophysical Journal
56 publications · 4.1K citations
36
h-index
Journal of Neurophysiology
JN · 55 publications · 3.8K citations
35
h-index

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