Concepedia

Passenger Mutation Accumulation

Passenger Mutation Accumulation is a biological phenomenon in cancer genomics wherein genetically neutral mutations, which do not confer a selective growth advantage, persist and increase in frequency within a tumor lineage due to their occurrence in cells that are clonally expanded by driver mutations.

9

Publications

1.2K

Citations

60

Authors

38

Institutions

Publications per year

2017–2026

3

Parents

Publications

9

Passenger deletions generate therapeutic vulnerabilities in cancer

Florian L. Müller, Simona Colla, Elisa Aquilanti et al. · Nature · 2012 · 356 citations

, , +10

Impact of deleterious passenger mutations on cancer progression

Christopher D. McFarland, Kirill S. Korolev, Gregory V. Kryukov et al. · Proceedings of the National Academy of Sciences · 2013 · 343 citations · Full text

, , +17

Passenger Mutations in More Than 2,500 Cancer Genomes: Overall Molecular Functional Impact and Consequences

Sushant Kumar, Jonathan Warrell, Shantao Li et al. · Cell · 2020 · 167 citations · Full text

, , +17

The Damaging Effect of Passenger Mutations on Cancer Progression

Christopher D. McFarland, Julia A. Yaglom, Jonathan W. Wojtkowiak et al. · Cancer Research · 2017 · 123 citations · Full text

, , +15

Evolutionary triage governs fitness in driver and passenger mutations and suggests targeting never mutations

Robert A. Gatenby, Jessica J. Cunningham, Joel S. Brown · Nature Communications · 2014 · 93 citations · Full text

, , +13

1–5 of 9

Authors

60

  1. LA
    Leonid A. Mirny

    Massachusetts Institute of Technology, United States

    3 publications · 477 citations

    3

    h-index

  2. CD
    Christopher D. McFarland

    Stanford University, United States

    3 publications · 477 citations

    3

    h-index

  3. KS
    Kirill S. Korolev

    Boston University, United States

    2 publications · 354 citations

    2

    h-index

  4. ES
    Ergün Sahin

    Harvard University, United States

    1 publications · 356 citations

    1

    h-index

  5. NL
    Natalia L. Komarova

    University of California, Irvine, United States

    1 publications · 45 citations

    1

    h-index

1–5 of 60

Institutions

38

  1. Harvard University

    Cambridge, United States

    4 h-index

    13 publications

    3.7K citations

  2. Massachusetts Institute of Technology

    Cambridge, United States

    3 h-index

    5 publications

    831 citations

  3. Moffitt Cancer Center

    Tampa, United States

    2 h-index

    4 publications

    432 citations

  4. Broad Institute

    Cambridge, United States

    2 h-index

    4 publications

    1.2K citations

  5. Boston University

    Boston, United States

    2 h-index

    3 publications

    257 citations

  6. The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute

    Columbus, United States

    1 h-index

    1 publications

    167 citations

  7. Aarhus University

    Aarhus, Denmark

    1 h-index

    1 publications

    167 citations

  8. Brigham and Women's Hospital

    Boston, United States

    1 h-index

    2 publications

    686 citations

1–8 of 38

Venues

  1. Journal of The Royal Society Interface

    1 publications · 45 citations

    1

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 1 publications · 343 citations

    1

    h-index

  3. Nature

    1 publications · 356 citations

    1

    h-index

  4. bioRxiv (Cold Spring Harbor Laboratory)

    Repository · 1 publications · 11 citations

    1

    h-index

  5. Journal of Theoretical Biology

    1 publications · 35 citations

    1

    h-index

1–5