Concepedia

Oxyanion Hole Function

Oxyanion Hole Function is a structural biochemical mechanism within enzyme active sites that stabilizes the negatively charged transition state of a substrate during catalysis by providing precisely oriented hydrogen bond donors to interact with the developing oxyanion.

155

Publications

8.4K

Citations

770

Authors

286

Institutions

Publications per year

2017–2026

21

Parents

Publications

155

Crystal Structure of Pseudomonas aeruginosa Lipase in the Open Conformation

Marco Nardini, Dietmar Lang, Klaus Liebeton et al. · Journal of Biological Chemistry · 2000 · 284 citations · Full text

, , +17

A Structural Framework for Deciphering the Link Between I-A <sup>g7</sup> and Autoimmune Diabetes

Adam L. Corper, Thomas Stratmann, Vasso Apostolopoulos et al. · Science · 2000 · 254 citations

, , +17

Site-directed mutagenesis and the role of the oxyanion hole in subtilisin.

Philip N. Bryan, Michael W. Pantoliano, Steven Quill et al. · Proceedings of the National Academy of Sciences · 1986 · 240 citations · Full text

, , +17

X-ray crystallographic study of boronic acid adducts with subtilisin BPN' (Novo). A model for the catalytic transition state.

David A. Matthews, Richard A. Alden, Jens J. Birktoft et al. · Journal of Biological Chemistry · 1975 · 223 citations · Full text

, , +17

Activation of Bacterial Thermoalkalophilic Lipases Is Spurred by Dramatic Structural Rearrangements

César Carrasco‐López, César A. Godoy, Blanca de las Rivas et al. · Journal of Biological Chemistry · 2008 · 219 citations · Full text

, , +17

1–5 of 155

Authors

770

  1. RK
    Rik K. Wierenga

    University of Oulu, Finland

    4 publications · 207 citations

    4

    h-index

  2. LS
    Luis Simón

    Universidad de Salamanca, Spain

    4 publications · 78 citations

    4

    h-index

  3. FM
    Francisco M. Muñiz

    Universidad de Salamanca, Spain

    4 publications · 78 citations

    4

    h-index

  4. JR
    Joaquı́n R. Morán

    Universidad de Salamanca, Spain

    4 publications · 78 citations

    4

    h-index

  5. ED
    Enrico Di

    Washington University in St. Louis, United States

    4 publications · 139 citations

    4

    h-index

1–5 of 770

Institutions

286

  1. Centre National de la Recherche Scientifique

    Paris, France

    6 h-index

    23 publications

    1.2K citations

  2. Universitat de Barcelona

    Barcelona, Spain

    5 h-index

    13 publications

    257 citations

  3. Stanford University

    Stanford, United States

    4 h-index

    15 publications

    1K citations

  4. Roche (Switzerland)

    Basel, Switzerland

    4 h-index

    10 publications

    230 citations

  5. University of Oulu

    Oulu, Finland

    4 h-index

    16 publications

    800 citations

  6. University of California San Diego

    San Diego, United States

    4 h-index

    15 publications

    2.3K citations

  7. University of Illinois Urbana-Champaign

    Urbana, United States

    4 h-index

    9 publications

    771 citations

  8. University of Oxford

    Oxford, United Kingdom

    4 h-index

    16 publications

    1.7K citations

1–8 of 286

Venues

  1. Biochemistry

    21 publications · 1.2K citations

    19

    h-index

  2. Journal of Biological Chemistry

    JBC · 12 publications · 1.3K citations

    12

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 8 publications · 863 citations

    8

    h-index

  4. Journal of the American Chemical Society

    JACS · 8 publications · 556 citations

    8

    h-index

  5. Biochemical Journal

    BJ · 5 publications · 191 citations

    5

    h-index

1–5