Concepedia

Oncogene Dosage Effects

Oncogene Dosage Effects is a biological phenomenon in which the quantitative level of oncogene expression or copy number directly influences the intensity or probability of tumorigenic cellular outcomes, distinguishing it from binary models of oncogene activation by emphasizing graded, dose-dependent responses in cancer progression.

12

Publications

818

Citations

67

Authors

33

Institutions

Publications per year

2017–2026

1

Parents

Publications

12

Oct-3/4 is a dose-dependent oncogenic fate determinant

Sharon Gidekel, Galina Pizov, Yehudit Bergman et al. · Cancer Cell · 2003 · 441 citations · Full text

, , +9

Endogenous oncogenic Nras mutation initiates hematopoietic malignancies in a dose- and cell type-dependent manner

Jinyong Wang, Yangang Liu, Zeyang Li et al. · Blood · 2011 · 97 citations

, , +14

Dominant Role of Oncogene Dosage and Absence of Tumor Suppressor Activity in <i>Nras-</i> Driven Hematopoietic Transformation

Jin Xu, Kevin M. Haigis, Ari J. Firestone et al. · Cancer Discovery · 2013 · 68 citations · Full text

, , +17

Dose effects of transfected c-Ha-rasVal 12 oncogene in transformed cell clones

Lea Sistonen, Jorma Keski‐Oja, Ismo Ulmanen et al. · Experimental Cell Research · 1987 · 58 citations

, , +16

MYC ecDNA promotes intratumour heterogeneity and plasticity in PDAC

Elena Fiorini, Antonia Malinova, Daniel Schreyer et al. · Nature · 2025 · 41 citations · Full text

, , +16

1–5 of 12

Authors

67

  1. MZ
    Mark Zervas

    Brown University, United States

    1 publications · 21 citations

    1

    h-index

  2. UB
    U. Bosse

    St. Elisabeth-Hospital Bochum, Germany

    1 publications · 11 citations

    1

    h-index

  3. GP
    Galina Pizov

    Hebrew University of Jerusalem, Israel

    1 publications · 441 citations

    1

    h-index

  4. MS
    Mahesh Shrestha

    Cincinnati Children's Hospital Medical Center, United States

    1 publications · 16 citations

    1

    h-index

  5. FM
    Frédérick Masson

    Walter and Eliza Hall Institute of Medical Research, Australia

    1 publications · 10 citations

    1

    h-index

1–5 of 67

Institutions

33

  1. Olivia Newton-John Cancer Wellness & Research Centre

    Heidelberg, Australia

    1 h-index

    7 publications

    70 citations

  2. Åbo Akademi University

    Turku, Finland

    1 h-index

    1 publications

    58 citations

  3. St. Jude Children's Research Hospital

    Memphis, United States

    1 h-index

    12 publications

    816 citations

  4. Center for Cancer Research

    Bethesda, United States

    1 h-index

    12 publications

    816 citations

  5. Brown University

    Providence, United States

    1 h-index

    2 publications

    42 citations

  6. Gdańsk Medical University

    Gdansk, Poland

    1 h-index

    2 publications

    22 citations

  7. University of Wisconsin–Madison

    Madison, United States

    1 h-index

    9 publications

    873 citations

  8. The Ohio State University

    Columbus, United States

    1 h-index

    1 publications

    16 citations

1–8 of 33

Venues

  1. genesis

    1 publications · 10 citations

    1

    h-index

  2. Experimental Cell Research

    ECR · 1 publications · 58 citations

    1

    h-index

  3. Cancer Letters

    1 publications · 23 citations

    1

    h-index

  4. Cancer Genetics and Cytogenetics

    1 publications · 35 citations

    1

    h-index

  5. Blood

    1 publications · 97 citations

    1

    h-index

1–5