Concepedia

On-resin Cyclization

On-Resin Cyclization is a method in solid-phase synthesis wherein a cyclic molecular structure is formed directly on a resin-bound intermediate, enabling the intramolecular coupling of functional groups while the substrate remains anchored to the solid support.

38

Publications

1.9K

Citations

166

Authors

63

Institutions

Publications per year

2017–2026

5

Parents

Publications

38

On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds

Tina R. White, Chad M. Renzelman, Arthur C Rand et al. · Nature Chemical Biology · 2011 · 384 citations

, , +10

Synthesis and Conformational Analysis of a Cyclic Peptide Obtained via <i>i</i> to <i>i</i>+4 Intramolecular Side-Chain to Side-Chain Azide−Alkyne 1,3-Dipolar Cycloaddition

Sonia Cantel, Alexandra Le Chevalier Isaad, Mario Scrima et al. · The Journal of Organic Chemistry · 2008 · 187 citations

, , +15

Click Chemistry as a Macrocyclization Tool in the Solid-Phase Synthesis of Small Cyclic Peptides

Rushia Turner, Allen G. Oliver, R. Scott Lokey · Organic Letters · 2007 · 159 citations

, , +15

On-resin peptide macrocyclization using thiol–ene click chemistry

Alex A. Aimetti, R. L. Shoemaker, Chien‐Chi Lin et al. · Chemical Communications · 2010 · 98 citations

, , +10

Global Analysis of Peptide Cyclization Efficiency

Amit Thakkar, Thi B. Trinh, Dehua Pei · ACS Combinatorial Science · 2012 · 91 citations

, , +15

1–5 of 38

Authors

166

  1. AM
    Anna Maria Papini

    University of Florence, Italy

    2 publications · 259 citations

    2

    h-index

  2. AA
    Alex A. Aimetti

    Marinus Pharmaceuticals (United States), United States

    2 publications · 150 citations

    2

    h-index

  3. LH
    Lena Hansen

    Ferring Pharmaceuticals (Denmark), Denmark

    2 publications · 31 citations

    2

    h-index

  4. FB
    Fabrizio Badalassi

    University of Pisa, Italy

    2 publications · 31 citations

    2

    h-index

  5. YY
    Yi Yang

    Merck & Co., Inc., Rahway, NJ, USA (United States), United States

    2 publications · 31 citations

    2

    h-index

1–5 of 166

Institutions

63

  1. Hong Kong University of Science and Technology

    Hong Kong, Hong Kong

    3 h-index

    10 publications

    272 citations

  2. Universitat de Barcelona

    Barcelona, Spain

    3 h-index

    7 publications

    130 citations

  3. University of Colorado Boulder

    Boulder, United States

    2 h-index

    7 publications

    548 citations

  4. University of Hong Kong

    Pok Fu Lam, Hong Kong

    2 h-index

    3 publications

    68 citations

  5. Howard Hughes Medical Institute

    Chevy Chase, United States

    2 h-index

    3 publications

    248 citations

  6. Inserm

    Paris, France

    2 h-index

    8 publications

    351 citations

  7. Institute for Research in Biomedicine

    Barcelona, Spain

    2 h-index

    3 publications

    76 citations

  8. University of California, Santa Cruz

    Santa Cruz, United States

    2 h-index

    11 publications

    3.5K citations

1–8 of 63

Venues

  1. The Journal of Organic Chemistry

    JOC · 8 publications · 414 citations

    8

    h-index

  2. Bioorganic & Medicinal Chemistry Letters

    4 publications · 134 citations

    4

    h-index

  3. Organic Letters

    OL · 4 publications · 289 citations

    4

    h-index

  4. Chemical Communications

    ChemComm · 4 publications · 220 citations

    4

    h-index

  5. Organic Process Research & Development

    2 publications · 31 citations

    2

    h-index

1–5