Concepedia

Off-pathway Intermediates

Off-Pathway Intermediates is a folding intermediate that belongs to the class of partially folded protein conformations but is distinguished by its failure to proceed directly toward the native functional structure, instead representing a kinetically trapped state separated from the productive folding pathway by an energy barrier.

74

Publications

4.8K

Citations

290

Authors

130

Institutions

Publications per year

2017–2026

17

Parents

Publications

74

The Complex Folding Network of Single Calmodulin Molecules

Johannes Stigler, Fabian Ziegler, Anja Gieseke et al. · Science · 2011 · 381 citations

, , +17

On-pathway versus off-pathway folding intermediates

Robert L. Baldwin · Folding and Design · 1996 · 258 citations

, , +17

Global Suppression of Protein Folding Defects and Inclusion Body Formation

Anna Mitraki, Bentley A. Fane, Cameron Haase‐Pettingell et al. · Science · 1991 · 209 citations

, , +17

Formation of aggregates from a thermolabile in vivo folding intermediate in P22 tailspike maturation. A model for inclusion body formation.

Cameron Haase‐Pettingell, Jonathan King · Journal of Biological Chemistry · 1988 · 198 citations · Full text

, , +17

Dual Molecular Signals Mediate the Bacterial Response to Outer-Membrane Stress

Santiago Lima, Monica S. Guo, Rachna Chaba et al. · Science · 2013 · 190 citations · Full text

, , +17

1–5 of 74

Authors

290

  1. CP
    Carlo P. M. van Mierlo

    Wageningen University & Research, Netherlands

    6 publications · 234 citations

    6

    h-index

  2. AH
    Adrie H. Westphal

    Wageningen University & Research, Netherlands

    4 publications · 142 citations

    4

    h-index

  3. JK
    Jonathan King

    Massachusetts Institute of Technology, United States

    4 publications · 544 citations

    4

    h-index

  4. SM
    Sanne M. Nabuurs

    Wageningen University & Research, Netherlands

    4 publications · 152 citations

    4

    h-index

  5. CR
    C. Robert Matthews

    Pennsylvania State University, United States

    3 publications · 221 citations

    3

    h-index

1–5 of 290

Institutions

130

  1. Wageningen University & Research

    Wageningen, The Netherlands

    5 h-index

    19 publications

    725 citations

  2. Massachusetts Institute of Technology

    Cambridge, United States

    5 h-index

    12 publications

    1.9K citations

  3. University of Toronto

    Toronto, Canada

    3 h-index

    6 publications

    749 citations

  4. National Institutes of Health

    Bethesda, United States

    3 h-index

    3 publications

    122 citations

  5. University of Michigan

    Ann Arbor, United States

    3 h-index

    12 publications

    1.1K citations

  6. Aarhus University

    Aarhus, Denmark

    3 h-index

    15 publications

    647 citations

  7. Universidad de Zaragoza

    Zaragoza, Spain

    3 h-index

    13 publications

    542 citations

  8. University College London

    London, United Kingdom

    2 h-index

    5 publications

    266 citations

1–8 of 130

Venues

  1. Biochemistry

    10 publications · 453 citations

    10

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 9 publications · 744 citations

    9

    h-index

  3. Journal of Biological Chemistry

    JBC · 9 publications · 488 citations

    9

    h-index

  4. Journal of the American Chemical Society

    JACS · 6 publications · 444 citations

    6

    h-index

  5. The Journal of Physical Chemistry B

    5 publications · 151 citations

    5

    h-index

1–5