Concepedia

Noncompetitive Binding

Noncompetitive Binding is a type of ligand binding interaction in which a ligand binds to an allosteric site on a receptor or enzyme, distinct from the active site, thereby modulating the protein's activity without preventing the primary ligand from binding, but altering the receptor's functional response.

170

Publications

8.9K

Citations

868

Authors

281

Institutions

Publications per year

2017–2026

20

Parents

Publications

170

Monoclonal anti-epidermal growth factor receptor antibodies which are inhibitors of epidermal growth factor binding and antagonists of epidermal growth factor binding and antagonists of epidermal growth factor-stimulated tyrosine protein kinase activity.

Gordon N. Gill, Tomoyuki Kawamoto, Claude Cochet et al. · Journal of Biological Chemistry · 1984 · 458 citations · Full text

, , +17

Nonpeptide angiotensin II receptor antagonists. VIII. Characterization of functional antagonism displayed by DuP 753, an orally active antihypertensive agent.

Pancras C. Wong, William A. Price, Andrew T. Chiu et al. · Journal of Pharmacology and Experimental Therapeutics · 1990 · 270 citations

, , +14

Carbonic Anhydrase Activators:  X-ray Crystallographic and Spectroscopic Investigations for the Interaction of Isozymes I and II with Histamine<sup>,</sup>

Fabrizio Briganti, Stefano Mangani, Pierluigi Orioli et al. · Biochemistry · 1997 · 270 citations

, , +17

X-linked Inhibitor of Apoptosis Protein (XIAP) Inhibits Caspase-3 and -7 in Distinct Modes

Yasuyuki Suzuki, Yui Nakabayashi, Kazuko Nakata et al. · Journal of Biological Chemistry · 2001 · 233 citations · Full text

, , +14

Nitric oxide inhibition of respiration involves both competitive (heme) and noncompetitive (copper) binding to cytochrome <i>c</i> oxidase

Maria G. Mason, Peter Nicholls, Michael T. Wilson et al. · Proceedings of the National Academy of Sciences · 2006 · 232 citations · Full text

, , +17

1–5 of 170

Authors

868

  1. BL
    Bernabé L. Rivas

    University of Concepción, Chile

    4 publications · 93 citations

    4

    h-index

  2. JH
    Jang Hoon Kim

    Chungnam National University, South Korea

    3 publications · 62 citations

    3

    h-index

  3. HR
    Hugo R. Arias

    Novartis (Switzerland), Switzerland

    3 publications · 66 citations

    3

    h-index

  4. OÇ
    Onur Çil

    University of California, San Francisco, United States

    2 publications · 49 citations

    2

    h-index

  5. UR
    Umesh R. Desai

    Virginia Commonwealth University, United States

    2 publications · 50 citations

    2

    h-index

1–5 of 868

Institutions

281

  1. University of Utah

    Salt Lake City, United States

    4 h-index

    14 publications

    942 citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    4 h-index

    11 publications

    602 citations

  3. University of Concepción

    Concepción, Chile

    4 h-index

    9 publications

    228 citations

  4. Consejo Nacional de Investigaciones Científicas y Técnicas

    Buenos Aires, Argentina

    3 h-index

    9 publications

    168 citations

  5. University of Maryland, Baltimore

    Baltimore, United States

    3 h-index

    9 publications

    323 citations

  6. Emory University

    Atlanta, United States

    3 h-index

    13 publications

    300 citations

  7. Chungnam National University

    Daejeon, South Korea

    3 h-index

    10 publications

    198 citations

  8. Novartis Institutes for BioMedical Research

    Basel, Switzerland

    3 h-index

    14 publications

    819 citations

1–8 of 281

Venues

  1. Journal of Biological Chemistry

    JBC · 15 publications · 1.4K citations

    15

    h-index

  2. Biochemistry

    13 publications · 760 citations

    12

    h-index

  3. Molecular Pharmacology

    11 publications · 643 citations

    11

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 10 publications · 925 citations

    10

    h-index

  5. Journal of Medicinal Chemistry

    10 publications · 428 citations

    10

    h-index

1–5