Concepedia

Negative Genetic Interactions

Negative Genetic Interactions is a type of genetic interaction characterized by the observation that the combined effect of two genetic perturbations results in a more severe fitness defect than expected from the individual effects, indicating functional compensatory or parallel pathways.

164

Publications

13.4K

Citations

786

Authors

301

Institutions

Publications per year

2017–2026

32

Parents

Publications

164

A global genetic interaction network maps a wiring diagram of cellular function

Michael Costanzo, Benjamin VanderSluis, Elizabeth N. Koch et al. · Science · 2016 · 1.4K citations · Full text

, , +15

Signatures of negative selection in the genetic architecture of human complex traits

Jian Zeng, Ronald de Vlaming, Yang Wu et al. · Nature Genetics · 2018 · 474 citations · Full text

, , +16

Genetic Interactions in Cancer Progression and Treatment

Alan Ashworth, Christopher J. Lord, Jorge S. Reis‐Filho · Cell · 2011 · 447 citations · Full text

, , +14

Competition among body parts in the development and evolution of insect morphology

H. Frederik Nijhout, Douglas J. Emlen · Proceedings of the National Academy of Sciences · 1998 · 421 citations

, , +17

<i>ASYMMETRIC LEAVES1</i>reveals<i>knox</i>gene redundancy in<i>Arabidopsis</i>

Mary E. Byrne, Joseph Simorowski, Robert A. Martienssen · Development · 2002 · 401 citations · Full text

, , +17

1–5 of 164

Authors

786

  1. CB
    Charles Boone

    University of Toronto, Canada

    6 publications · 2.1K citations

    6

    h-index

  2. BA
    Brenda Andrews

    University of Toronto, Canada

    5 publications · 2K citations

    5

    h-index

  3. CL
    Chad L. Myers

    University of Minnesota, United States

    4 publications · 1.9K citations

    4

    h-index

  4. AB
    Anastasia Baryshnikova

    University of Toronto, Canada

    4 publications · 2K citations

    4

    h-index

  5. GW
    Grant W. Brown

    University of Toronto, Canada

    3 publications · 490 citations

    3

    h-index

1–5 of 786

Institutions

301

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    10 h-index

    41 publications

    9.3K citations

  2. University of Toronto

    Toronto, Canada

    8 h-index

    92 publications

    49.4K citations

  3. University of Washington

    Seattle, United States

    6 h-index

    18 publications

    737 citations

  4. University of British Columbia

    Vancouver, Canada

    6 h-index

    14 publications

    1.5K citations

  5. University of California, Los Angeles

    Los Angeles, United States

    6 h-index

    10 publications

    1K citations

  6. Stanford University

    Stanford, United States

    5 h-index

    31 publications

    2.8K citations

  7. Centre National de la Recherche Scientifique

    Paris, France

    5 h-index

    16 publications

    1.5K citations

  8. National Institutes of Health

    Bethesda, United States

    4 h-index

    11 publications

    283 citations

1–8 of 301

Venues

  1. Evolution

    13 publications · 681 citations

    12

    h-index

  2. Genetics

    7 publications · 341 citations

    7

    h-index

  3. Scientific Reports

    4 publications · 148 citations

    4

    h-index

  4. Heredity

    4 publications · 258 citations

    4

    h-index

  5. Journal of Evolutionary Biology

    JEB · 4 publications · 82 citations

    4

    h-index

1–5