Concepedia

Nascent Chain Compaction

Nascent Chain Compaction is the process by which a newly synthesized polypeptide chain undergoes structural condensation into a more densely packed conformation during translation, prior to full emergence from the ribosome exit tunnel, thereby representing a co-translational protein folding event distinct from post-translational folding mechanisms.

26

Publications

1.4K

Citations

107

Authors

53

Institutions

Publications per year

2017–2026

7

Parents

Publications

26

Translational tuning optimizes nascent protein folding in cells

Soo Jung Kim, Jae Seok Yoon, Hideki Shishido et al. · Science · 2015 · 205 citations

, , +17

A Nascent Secretory Protein 5 Traverse the Ribosome/Endoplasmic Reticulum Translocase Complex as an Extended Chain

Paul Whitley, IngMarie Nilsson, Gunnar von Heijne · Journal of Biological Chemistry · 1996 · 149 citations · Full text

, , +15

The force-sensing peptide VemP employs extreme compaction and secondary structure formation to induce ribosomal stalling

Ting Su, Jingdong Cheng, Daniel Sohmen et al. · eLife · 2017 · 111 citations · Full text

, , +17

New Scenarios of Protein Folding Can Occur on the Ribosome

Edward P. O’Brien, John Christodoulou, Michele Vendruscolo et al. · Journal of the American Chemical Society · 2011 · 101 citations

, , +17

Different conformations of nascent polypeptides during translocation across the ER membrane

Ismael Mingarro, Ing-Marie Nilsson, Paul Whitley et al. · BMC Cell Biology · 2000 · 90 citations · Full text

, , +17

1–5 of 26

Authors

107

  1. GV
    Gunnar von Heijne

    Stockholm University, Sweden

    4 publications · 434 citations

    4

    h-index

  2. JS
    Jae Seok Yoon

    Yonsei University, South Korea

    2 publications · 254 citations

    2

    h-index

  3. BB
    Bernd Bukau

    Heidelberg University, Germany

    2 publications · 136 citations

    2

    h-index

  4. RB
    Roland Beckmann

    Center for Integrated Protein Science Munich, Germany

    2 publications · 159 citations

    2

    h-index

  5. ZY
    Zhongying Yang

    Oregon Health & Science University, United States

    2 publications · 254 citations

    2

    h-index

1–5 of 107

Institutions

53

  1. Stockholm University

    Stockholm, Sweden

    4 h-index

    11 publications

    1.2K citations

  2. Ludwig-Maximilians-Universität München

    Munich, Germany

    3 h-index

    16 publications

    1.1K citations

  3. Heidelberg University

    Heidelberg, Germany

    2 h-index

    3 publications

    220 citations

  4. Oregon Health & Science University

    Portland, United States

    2 h-index

    7 publications

    1.3K citations

  5. Cystic Fibrosis Foundation

    Bethesda, United States

    2 h-index

    4 publications

    352 citations

  6. Science for Life Laboratory

    Stockholm, Sweden

    2 h-index

    2 publications

    195 citations

  7. Institute of Biostructure and Bioimaging

    Naples, Italy

    2 h-index

    3 publications

    56 citations

  8. Tata Institute of Fundamental Research

    Mumbai, India

    1 h-index

    5 publications

    225 citations

1–8 of 53

Venues

  1. Journal of Molecular Biology

    JMB · 6 publications · 273 citations

    6

    h-index

  2. Journal of Biological Chemistry

    JBC · 3 publications · 212 citations

    3

    h-index

  3. The Journal of Physical Chemistry B

    2 publications · 36 citations

    2

    h-index

  4. eLife

    2 publications · 166 citations

    2

    h-index

  5. Science

    1 publications · 205 citations

    1

    h-index

1–5