Concepedia

Mutational Load

Mutational Load is a genetic burden representing the reduction in population mean fitness due to the cumulative presence of deleterious mutations relative to an optimal genotype.

656

Publications

55.7K

Citations

5.4K

Authors

1.5K

Institutions

Publications per year

2017–2026

226

Parents

Publications

656

Mutational heterogeneity in cancer and the search for new cancer-associated genes

Michael S. Lawrence, Petar Stojanov, Paz Polak et al. · Nature · 2013 · 5.7K citations · Full text

, , +14

Tumor mutational load predicts survival after immunotherapy across multiple cancer types

Robert Samstein, Chung‐Han Lee, Alexander N. Shoushtari et al. · Nature Genetics · 2019 · 4.4K citations · Full text

, , +14

Primary Resistance to PD-1 Blockade Mediated by <i>JAK1/2</i> Mutations

Daniel Sanghoon Shin, Jesse M. Zaretsky, Helena Escuin-Ordinas et al. · Cancer Discovery · 2016 · 1.3K citations · Full text

, , +17

Impact of Mutational Testing on the Diagnosis and Management of Patients with Cytologically Indeterminate Thyroid Nodules: A Prospective Analysis of 1056 FNA Samples

Yuri E. Nikiforov, N. Paul Ohori, Steven P. Hodak et al. · The Journal of Clinical Endocrinology & Metabolism · 2011 · 789 citations · Full text

, , +13

Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity

Austin Dulak, Petar Stojanov, Shouyong Peng et al. · Nature Genetics · 2013 · 747 citations · Full text

, , +17

1–5 of 656

Authors

5.4K

  1. PD
    Peter D. Keightley

    University of Edinburgh, United Kingdom

    8 publications · 523 citations

    8

    h-index

  2. ML
    Michael Lynch

    Indiana University Bloomington, United States

    7 publications · 1.5K citations

    7

    h-index

  3. EJ
    Edward J. Klekowski

    University of Massachusetts Amherst, United States

    6 publications · 183 citations

    6

    h-index

  4. BC
    Brian Charlesworth

    University of Edinburgh, United Kingdom

    5 publications · 609 citations

    5

    h-index

  5. AF
    Aneil F. Agrawal

    University of Toronto, Canada

    5 publications · 488 citations

    5

    h-index

1–5 of 5.4K

Institutions

1.5K

  1. University of Edinburgh

    Edinburgh, United Kingdom

    18 h-index

    41 publications

    3.8K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    17 h-index

    71 publications

    3.1K citations

  3. Dana-Farber Cancer Institute

    Boston, United States

    16 h-index

    116 publications

    125.4K citations

  4. Harvard University

    Cambridge, United States

    15 h-index

    100 publications

    108.5K citations

  5. Uppsala University

    Uppsala, Sweden

    14 h-index

    54 publications

    3.3K citations

  6. Inserm

    Paris, France

    14 h-index

    65 publications

    4.2K citations

  7. University of Toronto

    Toronto, Canada

    14 h-index

    40 publications

    3.9K citations

  8. Howard Hughes Medical Institute

    Chevy Chase, United States

    13 h-index

    51 publications

    16.9K citations

1–8 of 1.5K

Venues

  1. Evolution

    38 publications · 2.8K citations

    28

    h-index

  2. Genetics

    34 publications · 3.3K citations

    27

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 24 publications · 2.4K citations

    20

    h-index

  4. Oncotarget

    14 publications · 1.2K citations

    14

    h-index

  5. Nature Communications

    14 publications · 1.5K citations

    14

    h-index

1–5