Concepedia

Mutational Hotspot Control

Mutational Hotspot Control is a methodological framework in error-prone mutagenesis that enables the targeted regulation of mutation frequency at specific genomic loci by modulating sequence context or mutagenic conditions to enhance genetic diversity in predetermined regions.

26

Publications

1.2K

Citations

156

Authors

43

Institutions

Publications per year

2017–2026

3

Parents

Publications

26

Recurrent mutations in haemophilia A give evidence for CpG mutation hotspots

Hagop Youssoufian, Haig H. Kazazian, Deborah G. Phillips et al. · Nature · 1986 · 266 citations

, , +11

Crystal Structure of Penicillin-binding Protein 1a (PBP1a) Reveals a Mutational Hotspot Implicated in β-Lactam Resistance in Streptococcus pneumoniae

Carlos Contreras‐Martel, Viviana Job, Anne Marie Di Guilmi et al. · Journal of Molecular Biology · 2005 · 89 citations

, , +17

Affinity maturation of a VHH by mutational hotspot randomization

Kerrm Y. F. Yau, G. Dubuc, Shenghua Li et al. · Journal of Immunological Methods · 2005 · 81 citations

, , +7

PAX2 mutations in renal–coloboma syndrome: mutational hotspot and germline mosaicism

Jeanne Amiel, Sophie Audollent, Dominique Joly et al. · European Journal of Human Genetics · 2000 · 79 citations

, , +17

Mutational hotspot in the human biotinidase gene causes profound biotinidase deficiency

Robert J. Pomponio, Thomas Reynolds, Heath Cole et al. · Nature Genetics · 1995 · 77 citations

, , +15

1–5 of 26

Authors

156

  1. NK
    Nicole Koffel-Schwartz

    Centre National de la Recherche Scientifique, France

    2 publications · 85 citations

    2

    h-index

  2. RP
    Robert P. Fuchs

    Centre National de la Recherche Scientifique, France

    2 publications · 85 citations

    2

    h-index

  3. MM
    Michael M. Seidman

    National Institute on Aging, United States

    2 publications · 55 citations

    2

    h-index

  4. ST
    Susan T. Lovett

    Brandeis University, United States

    2 publications · 144 citations

    2

    h-index

  5. RL
    Rebecca L. Hurley

    Dartmouth College, United States

    1 publications · 74 citations

    1

    h-index

1–5 of 156

Institutions

43

  1. Centre National de la Recherche Scientifique

    Paris, France

    4 h-index

    16 publications

    831 citations

  2. Brandeis University

    Waltham, United States

    2 h-index

    6 publications

    436 citations

  3. Otsuka Pharmaceutical (Spain)

    Barcelona, Spain

    1 h-index

    1 publications

    17 citations

  4. Tel Aviv University

    Tel Aviv, Israel

    1 h-index

    9 publications

    189 citations

  5. University of Chicago

    Chicago, United States

    1 h-index

    1 publications

    13 citations

  6. Baylor College of Medicine

    Houston, United States

    1 h-index

    1 publications

    77 citations

  7. University of Szeged

    Szeged, Hungary

    1 h-index

    5 publications

    100 citations

  8. CEA Grenoble

    Grenoble, France

    1 h-index

    6 publications

    534 citations

1–8 of 43

Venues

  1. Journal of Molecular Biology

    JMB · 8 publications · 412 citations

    8

    h-index

  2. Diabetes

    2 publications · 72 citations

    2

    h-index

  3. Nucleic Acids Research

    1 publications · 17 citations

    1

    h-index

  4. Thrombosis and Haemostasis

    1 publications · 24 citations

    1

    h-index

  5. Cell

    1 publications · 24 citations

    1

    h-index

1–5