Concepedia

Mutational Folding Effects

Mutational Folding Effects is a biophysical phenomenon characterized by the alteration in the folding kinetics and thermodynamic stability of a protein resulting from amino acid substitutions, distinguishing it from other factors influencing protein folding by specifically implicating sequence-level mutations as the primary cause.

179

Publications

10K

Citations

634

Authors

243

Institutions

Publications per year

2017–2026

19

Parents

Publications

179

Additivity of mutational effects in proteins

James Wells · Biochemistry · 1990 · 669 citations

, , +10

Can AlphaFold2 predict the impact of missense mutations on structure?

Nature Structural & Molecular Biology · 2022 · 340 citations · Full text

, , +12

Using AlphaFold to predict the impact of single mutations on protein stability and function

Marina A. Pak, Karina A. Markhieva, Mariia S. Novikova et al. · PLoS ONE · 2023 · 288 citations · Full text

, , +13

Synonymous codon substitutions perturb cotranslational protein folding in vivo and impair cell fitness

Ian M. Walsh, Micayla A. Bowman, Iker F. Soto Santarriaga et al. · Proceedings of the National Academy of Sciences · 2020 · 247 citations · Full text

, , +17

Engineered turns of a recombinant antibody improve its <i>in vivo</i> folding

Achim Knappik, Andreas Plückthun · Protein Engineering Design and Selection · 1995 · 238 citations · Full text

, , +17

1–5 of 179

Authors

634

  1. MM
    M. Michael Gromiha

    Indian Institute of Technology Madras, India

    5 publications · 160 citations

    5

    h-index

  2. RS
    Robert Seckler

    University of Potsdam, Germany

    4 publications · 191 citations

    4

    h-index

  3. RL
    Robert L. Baldwin

    Stanford University, United States

    4 publications · 198 citations

    4

    h-index

  4. BB
    Barbara Brodsky

    Rutgers, The State University of New Jersey, United States

    4 publications · 177 citations

    4

    h-index

  5. JK
    Jonathan King

    Massachusetts Institute of Technology, United States

    3 publications · 177 citations

    3

    h-index

1–5 of 634

Institutions

243

  1. Harvard University

    Cambridge, United States

    6 h-index

    12 publications

    1.6K citations

  2. Stanford University

    Stanford, United States

    6 h-index

    19 publications

    1.1K citations

  3. Massachusetts Institute of Technology

    Cambridge, United States

    6 h-index

    13 publications

    1K citations

  4. Columbia University

    New York, United States

    4 h-index

    8 publications

    307 citations

  5. Max Planck Institute of Biochemistry

    Martinsried, Germany

    4 h-index

    14 publications

    798 citations

  6. University of California San Diego

    San Diego, United States

    4 h-index

    13 publications

    330 citations

  7. University of Regensburg

    Regensburg, Germany

    4 h-index

    10 publications

    485 citations

  8. University of Milan

    Milan, Italy

    4 h-index

    11 publications

    496 citations

1–8 of 243

Venues

  1. Biochemistry

    39 publications · 2.6K citations

    27

    h-index

  2. Journal of Molecular Biology

    JMB · 13 publications · 662 citations

    13

    h-index

  3. Protein Science

    PS · 14 publications · 563 citations

    12

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 12 publications · 1.3K citations

    12

    h-index

  5. Journal of Biological Chemistry

    JBC · 11 publications · 618 citations

    11

    h-index

1–5