Mutational Constraint is a theoretical construct in evolutionary biology that refers to the limitation on phenotypic variation arising from the absence, rarity, or inaccessibility of certain mutations within a population’s genetic repertoire.
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26.8K
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2017–2026
43
Variants
Mutational Constraints
Parents
Publications
160
The mutational constraint spectrum quantified from variation in 141,456 humans
Konrad J. Karczewski, Laurent C. Francioli, Grace Tiao et al. · Nature · 2020 · 10.1K citations · Full text
A genomic mutational constraint map using variation in 76,156 human genomes
Siwei Chen, Laurent C. Francioli, Julia K. Goodrich et al. · Nature · 2023 · 1.3K citations · Full text
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1–5 of 870
Institutions
435
University of Oxford
Oxford, United Kingdom
9 h-index
17 publications
25.3K citations
Broad Institute
Cambridge, United States
8 h-index
300 publications
1M citations
Centre National de la Recherche Scientifique
Paris, France
8 h-index
24 publications
2K citations
Harvard University
Cambridge, United States
7 h-index
49 publications
175.9K citations
University of Washington
Seattle, United States
7 h-index
18 publications
14.8K citations
Massachusetts General Hospital
Boston, United States
6 h-index
121 publications
549.6K citations
Howard Hughes Medical Institute
Chevy Chase, United States
6 h-index
11 publications
2.4K citations
Yale University
New Haven, United States
5 h-index
9 publications
26.6K citations
1–8 of 435
Venues
- Genetics
12 publications · 1.9K citations
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- Molecular Biology and Evolution
MBE · 10 publications · 707 citations
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- Proceedings of the National Academy of Sciences
PNAS · 9 publications · 1.1K citations
9
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- Evolution
8 publications · 615 citations
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- Nature
5 publications · 12.2K citations
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