Concepedia

Mutation Accumulation Experiments

Mutation Accumulation Experiments is a research methodology in microbial experimental evolution that systematically minimizes the efficiency of natural selection to allow the gradual buildup of neutral and nearly neutral mutations, thereby enabling the study of spontaneous mutation rates, spectra, and their fitness effects over time.

173

Publications

13.2K

Citations

538

Authors

238

Institutions

Publications per year

2017–2026

55

Variants

Ma Experiments

Parents

Publications

173

Tissue-specific mutation accumulation in human adult stem cells during life

Francis Blokzijl, Joep de Ligt, Myrthe Jager et al. · Nature · 2016 · 984 citations · Full text

, , +13

Spontaneous Mutation Accumulation Studies in Evolutionary Genetics

Daniel L. Halligan, Peter D. Keightley · Annual Review of Ecology Evolution and Systematics · 2009 · 535 citations

, , +17

Precise estimates of mutation rate and spectrum in yeast

Yuan Zhu, Mark L. Siegal, David W. Hall et al. · Proceedings of the National Academy of Sciences · 2014 · 487 citations · Full text

, , +16

Mutation bias reflects natural selection in Arabidopsis thaliana

Nature · 2022 · 384 citations · Full text

, , +14

Mutation bias reflects natural selection in Arabidopsis thaliana

2022 · 340 citations

, , +14

1–5 of 173

Authors

538

  1. ML
    Michael Lynch

    Indiana University Bloomington, United States

    23 publications · 1.9K citations

    20

    h-index

  2. PD
    Peter D. Keightley

    University of Edinburgh, United Kingdom

    17 publications · 1.9K citations

    17

    h-index

  3. NC
    Nick Colegrave

    University of Edinburgh, United Kingdom

    8 publications · 503 citations

    8

    h-index

  4. RW
    Rob W. Ness

    University of Toronto, Canada

    7 publications · 480 citations

    7

    h-index

  5. WS
    Way Sung

    Indiana University Bloomington, United States

    6 publications · 496 citations

    6

    h-index

1–5 of 538

Institutions

238

  1. Indiana University Bloomington

    Bloomington, United States

    18 h-index

    69 publications

    6.4K citations

  2. University of Edinburgh

    Edinburgh, United Kingdom

    18 h-index

    61 publications

    5.1K citations

  3. University of Toronto

    Toronto, Canada

    8 h-index

    13 publications

    608 citations

  4. Arizona State University

    Tempe, United States

    7 h-index

    16 publications

    479 citations

  5. University of Oregon

    Eugene, United States

    7 h-index

    14 publications

    1.3K citations

  6. University of Oxford

    Oxford, United Kingdom

    6 h-index

    7 publications

    649 citations

  7. Stanford University

    Stanford, United States

    6 h-index

    10 publications

    1.7K citations

  8. University of Georgia

    Athens, United States

    5 h-index

    7 publications

    794 citations

1–8 of 238

Venues

  1. Genetics

    37 publications · 3.1K citations

    27

    h-index

  2. Evolution

    14 publications · 731 citations

    14

    h-index

  3. Molecular Biology and Evolution

    MBE · 11 publications · 587 citations

    11

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 8 publications · 1.4K citations

    8

    h-index

  5. Genome Biology and Evolution

    GBE · 8 publications · 274 citations

    8

    h-index

1–5