Concepedia

Munc18-mediated Fusion

Munc18-Mediated Fusion is a molecular mechanism in intracellular membrane trafficking that specifically denotes the regulated assembly of SNARE complexes facilitated by the Munc18 protein, which acts as a critical chaperone ensuring proper syntaxin conformation and fusion specificity during exocytosis.

121

Publications

9.5K

Citations

549

Authors

198

Institutions

Publications per year

2017–2026

27

Parents

Publications

121

Synaptic vesicle fusion complex contains unc-18 homologue bound to syntaxin

Yutaka Hata, Clive A. Slaughter, Thomas C. Südhof · Nature · 1993 · 712 citations

, , +14

Selective Activation of Cognate SNAREpins by Sec1/Munc18 Proteins

Jingshi Shen, David Tareste, Fabienne Paumet et al. · Cell · 2007 · 480 citations · Full text

, , +12

Reconstitution of the Vital Functions of Munc18 and Munc13 in Neurotransmitter Release

Cong Ma, Lijing Su, Alpay B. Seven et al. · Science · 2012 · 433 citations

, , +17

Munc18-1 binds directly to the neuronal SNARE complex

Irina Dulubova, Mikhail Khvotchev, Siqi Liu et al. · Proceedings of the National Academy of Sciences · 2007 · 351 citations · Full text

, , +16

Conformational Switch of Syntaxin-1 Controls Synaptic Vesicle Fusion

Stefan Gerber, Jong‐Cheol Rah, Sang-Won Min et al. · Science · 2008 · 292 citations

, , +17

1–5 of 121

Authors

549

  1. JR
    Josep Rizo

    The University of Texas Southwestern Medical Center, United States

    12 publications · 1.9K citations

    12

    h-index

  2. JS
    Jingshi Shen

    University of Colorado Boulder, United States

    10 publications · 1.1K citations

    10

    h-index

  3. TC
    Thomas C. Südhof

    Howard Hughes Medical Institute, United States

    9 publications · 2.4K citations

    9

    h-index

  4. NJ
    Nia J. Bryant

    University of Glasgow, United Kingdom

    7 publications · 305 citations

    7

    h-index

  5. SS
    Shailendra S. Rathore

    University of Colorado Boulder, United States

    7 publications · 449 citations

    7

    h-index

1–5 of 549

Institutions

198

  1. The University of Texas Southwestern Medical Center

    Dallas, United States

    14 h-index

    71 publications

    13.9K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    11 h-index

    38 publications

    6.9K citations

  3. Max Planck Institute for Biophysical Chemistry

    Göttingen, Germany

    10 h-index

    39 publications

    5.8K citations

  4. The University of Queensland

    Brisbane, Australia

    9 h-index

    47 publications

    2.9K citations

  5. University of Colorado Boulder

    Boulder, United States

    8 h-index

    38 publications

    1.9K citations

  6. University of Toronto

    Toronto, Canada

    7 h-index

    19 publications

    799 citations

  7. University Health Network

    Toronto, Canada

    6 h-index

    13 publications

    479 citations

  8. Yale University

    New Haven, United States

    6 h-index

    35 publications

    2.5K citations

1–8 of 198

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 17 publications · 1.5K citations

    17

    h-index

  2. Journal of Biological Chemistry

    JBC · 16 publications · 1.1K citations

    15

    h-index

  3. Molecular Biology of the Cell

    MBC · 7 publications · 369 citations

    7

    h-index

  4. The Journal of Cell Biology

    JCB · 7 publications · 740 citations

    7

    h-index

  5. PLoS ONE

    5 publications · 159 citations

    5

    h-index

1–5