Concepedia

Multistate Binding Models

Multistate Binding Models is a theoretical framework in molecular biophysics that describes ligand-receptor interactions by accounting for multiple conformational states of a biomolecule, distinguishing it from classical two-state models through its explicit representation of pre-existing equilibria among diverse structural conformations.

25

Publications

1.4K

Citations

98

Authors

57

Institutions

Publications per year

2017–2026

7

Variants

Multistate Binding Model

Parents

Publications

25

The two-state model of receptor activation

Paul Leff · Trends in Pharmacological Sciences · 1995 · 505 citations

, , +14

Multi-State Regulation of the Dihydrogen Phosphate Binding Affinity to a Light- and Heat-Responsive Bis-Urea Receptor

Sander J. Wezenberg, Matea Vlatković, Jos C. M. Kistemaker et al. · Journal of the American Chemical Society · 2014 · 90 citations · Full text

, , +17

NMR line shapes and multi-state binding equilibria

Evgenii L. Kovrigin · Journal of Biomolecular NMR · 2012 · 87 citations

, , +6

The Three-State Model: A Minimal Allosteric Description of Homotropic and Heterotropic Effects in the Binding of Ligands to Hemoglobin

Allen P. Minton, Kiyohiro Imai · Proceedings of the National Academy of Sciences · 1974 · 83 citations · Full text

, , +15

Concerted Interconversion between Ionic Lock Substates of the β2 Adrenergic Receptor Revealed by Microsecond Timescale Molecular Dynamics

Tod D. Romo, Alan Grossfield, Michael C. Pitman · Biophysical Journal · 2010 · 68 citations · Full text

, , +16

1–5 of 25

Authors

98

  1. EL
    Evgenii L. Kovrigin

    Marquette University, United States

    2 publications · 104 citations

    2

    h-index

  2. PL
    Paul Leff

    Loughborough University, United Kingdom

    2 publications · 564 citations

    2

    h-index

  3. AP
    Allen P. Minton

    National Institute of Diabetes and Digestive and Kidney Diseases, United States

    2 publications · 94 citations

    2

    h-index

  4. SD
    Steven D. Miklasz

    University of Illinois Urbana-Champaign, United States

    1 publications · 19 citations

    1

    h-index

  5. TK
    Terry Kenakin

    Research Triangle Park Foundation, United States

    1 publications · 21 citations

    1

    h-index

1–5 of 98

Institutions

57

  1. Loughborough University

    Loughborough, United Kingdom

    2 h-index

    5 publications

    741 citations

  2. National Institutes of Health

    Bethesda, United States

    2 h-index

    2 publications

    94 citations

  3. National Institute of Arthritis and Musculoskeletal and Skin Diseases

    Bethesda, United States

    2 h-index

    2 publications

    94 citations

  4. Marquette University

    Milwaukee, United States

    2 h-index

    3 publications

    121 citations

  5. European Bioinformatics Institute

    Cambridge, United Kingdom

    1 h-index

    3 publications

    60 citations

  6. University of Groningen

    Groningen, The Netherlands

    1 h-index

    4 publications

    360 citations

  7. University of Wisconsin–Madison

    Madison, United States

    1 h-index

    1 publications

    67 citations

  8. Research Triangle Park Foundation

    Durham, United States

    1 h-index

    1 publications

    21 citations

1–8 of 57

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 2 publications · 93 citations

    2

    h-index

  2. Journal of Biological Chemistry

    JBC · 2 publications · 70 citations

    2

    h-index

  3. Journal of Molecular Biology

    JMB · 2 publications · 83 citations

    2

    h-index

  4. Trends in Pharmacological Sciences

    2 publications · 564 citations

    2

    h-index

  5. Journal of Biomolecular NMR

    2 publications · 104 citations

    2

    h-index

1–5