Concepedia

Multisite Binding

Multisite Binding is a biochemical interaction mechanism in which a single substrate molecule simultaneously binds to two or more distinct sites on an enzyme or macromolecular complex, enhancing specificity, regulation, or catalytic efficiency.

91

Publications

6.4K

Citations

452

Authors

189

Institutions

Publications per year

2017–2026

16

Parents

Publications

91

Binding Site Diversity Promotes CO<sub>2</sub> Electroreduction to Ethanol

Yuguang Li, Ziyun Wang, Tiange Yuan et al. · Journal of the American Chemical Society · 2019 · 562 citations · Full text

, , +17

Structural Mechanisms of QacR Induction and Multidrug Recognition

Maria A. Schumacher, Marshall C. Miller, Steve Grkovic et al. · Science · 2001 · 368 citations

, , +15

Dynamic equilibrium engagement of a polyvalent ligand with a single-site receptor

Tanja Mittag, Stephen Orlicky, Wing‐Yiu Choy et al. · Proceedings of the National Academy of Sciences · 2008 · 343 citations · Full text

, , +17

Visual arrestin interaction with rhodopsin. Sequential multisite binding ensures strict selectivity toward light-activated phosphorylated rhodopsin

Vsevolod V. Gurevich, Jeffrey Benovic · Journal of Biological Chemistry · 1993 · 306 citations · Full text

, , +15

Interpreting Steep Dose-Response Curves in Early Inhibitor Discovery

Brian K. Shoichet · Journal of Medicinal Chemistry · 2006 · 298 citations

, , +14

1–5 of 91

Authors

452

  1. VV
    Vsevolod V. Gurevich

    Vanderbilt University, United States

    3 publications · 541 citations

    3

    h-index

  2. FC
    Friedrich Cramer

    Max Planck Institute of Experimental Medicine, Germany

    2 publications · 39 citations

    2

    h-index

  3. PP
    P. Palvadeau

    Centre National de la Recherche Scientifique, France

    2 publications · 25 citations

    2

    h-index

  4. PF
    Ping Fang

    Baylor College of Medicine, United States

    2 publications · 171 citations

    2

    h-index

  5. RJ
    Robert J. Schwartz

    Baylor College of Medicine, United States

    2 publications · 171 citations

    2

    h-index

1–5 of 452

Institutions

189

  1. Centre National de la Recherche Scientifique

    Paris, France

    5 h-index

    19 publications

    687 citations

  2. University of Cambridge

    Cambridge, United Kingdom

    4 h-index

    9 publications

    621 citations

  3. KU Leuven

    Leuven, Belgium

    3 h-index

    9 publications

    713 citations

  4. Oregon Health & Science University

    Portland, United States

    2 h-index

    5 publications

    1.1K citations

  5. University of California, San Francisco

    San Francisco, United States

    2 h-index

    8 publications

    739 citations

  6. Albert Einstein College of Medicine

    Bronx, United States

    2 h-index

    5 publications

    597 citations

  7. St. Jude Children's Research Hospital

    Memphis, United States

    2 h-index

    4 publications

    533 citations

  8. Tel Aviv University

    Tel Aviv, Israel

    2 h-index

    2 publications

    180 citations

1–8 of 189

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 8 publications · 987 citations

    8

    h-index

  2. Journal of the American Chemical Society

    JACS · 5 publications · 791 citations

    5

    h-index

  3. Journal of Biological Chemistry

    JBC · 5 publications · 676 citations

    5

    h-index

  4. Journal of Medicinal Chemistry

    3 publications · 334 citations

    3

    h-index

  5. Chemical Communications

    ChemComm · 3 publications · 84 citations

    3

    h-index

1–5