Concepedia

Multimodal Chromatography

Multimodal Chromatography is a chromatographic separation technique that, as a member of the affinity chromatography family, exploits multiple simultaneous interactions—such as hydrophobic, electrostatic, and hydrogen bonding—between the ligand and target molecule to achieve high selectivity and resolution under varying buffer conditions.

50

Publications

1.7K

Citations

182

Authors

63

Institutions

Publications per year

2017–2026

22

Parents

Publications

50

Multimodal liquid chromatography columns for the separation of proteins in either the anion-exchange or hydrophobic-interaction mode

Laura Kennedy, William Kopaciewicz, Fred E. Regnier · Journal of Chromatography A · 1986 · 123 citations

, , +13

Chiral Separations of Polar Compounds by Hydrophilic Interaction Chromatography with Evaporative Light Scattering Detection

Donald S. Risley, Mark A. Strege · Analytical Chemistry · 2000 · 86 citations

, , +14

Evaluation of protein adsorption and preferred binding regions in multimodal chromatography using NMR

Wai Keen Chung, Alexander S. Freed, Melissa Holstein et al. · Proceedings of the National Academy of Sciences · 2010 · 78 citations · Full text

, , +17

Multimodal chromatography: Characterization of protein binding and selectivity enhancement through mobile phase modulators

Leslie S. Wolfe, Cartney P Barringer, Sigma S. Mostafa et al. · Journal of Chromatography A · 2014 · 57 citations

, , +17

Mobile phase modifier effects in multimodal cation exchange chromatography

Melissa Holstein, Siddharth Parimal, Scott A. McCallum et al. · Biotechnology and Bioengineering · 2011 · 57 citations

, , +16

1–5 of 50

Authors

182

  1. SM
    Steven M. Cramer

    Rensselaer Polytechnic Institute, United States

    12 publications · 397 citations

    11

    h-index

  2. SP
    Siddharth Parimal

    Rensselaer Polytechnic Institute, United States

    5 publications · 172 citations

    5

    h-index

  3. AM
    Ana M. Azevedo

    Institute for Biotechnology and Bioengineering, Portugal

    5 publications · 157 citations

    5

    h-index

  4. DJ
    David J. Roush

    Merck & Co., Inc., Rahway, NJ, USA (United States), United States

    4 publications · 108 citations

    4

    h-index

  5. SG
    Shekhar Garde

    Rensselaer Polytechnic Institute, United States

    4 publications · 72 citations

    4

    h-index

1–5 of 182

Institutions

63

  1. Rensselaer Polytechnic Institute

    Troy, United States

    14 h-index

    53 publications

    1.8K citations

  2. Merck & Co., Inc., Rahway, NJ, USA (United States)

    Rahway, United States

    5 h-index

    14 publications

    376 citations

  3. Institute for Biotechnology and Bioengineering

    Lisbon, Portugal

    4 h-index

    16 publications

    387 citations

  4. University of Lisbon

    Lisbon, Portugal

    3 h-index

    13 publications

    282 citations

  5. Karlsruhe Institute of Technology

    Karlsruhe, Germany

    3 h-index

    8 publications

    246 citations

  6. University College London

    London, United Kingdom

    2 h-index

    4 publications

    112 citations

  7. Boehringer Ingelheim (Germany)

    Ingelheim, Germany

    2 h-index

    15 publications

    290 citations

  8. Lawrence Livermore National Laboratory

    Livermore, United States

    2 h-index

    2 publications

    25 citations

1–8 of 63

Venues

  1. Journal of Chromatography A

    18 publications · 685 citations

    17

    h-index

  2. Separation and Purification Technology

    4 publications · 84 citations

    4

    h-index

  3. Langmuir

    3 publications · 88 citations

    3

    h-index

  4. Biotechnology Progress

    3 publications · 88 citations

    3

    h-index

  5. Biotechnology and Bioengineering

    3 publications · 105 citations

    3

    h-index

1–5