Concepedia

Multimodal Affinity Chromatography

Multimodal Affinity Chromatography is a chromatographic technique that belongs to the class of affinity-based separation methods, distinguished by the use of ligands capable of simultaneous interaction with multiple types of molecular properties—such as hydrophobic, electrostatic, and hydrogen bonding forces—to achieve selective purification of biomolecules.

28

Publications

917

Citations

139

Authors

46

Institutions

Publications per year

2017–2026

12

Variants

Mixed-mode Affinity Chromatography

Parents

Publications

28

Evaluation of protein adsorption and preferred binding regions in multimodal chromatography using NMR

Wai Keen Chung, Alexander S. Freed, Melissa Holstein et al. · Proceedings of the National Academy of Sciences · 2010 · 78 citations · Full text

, , +17

Multimodal chromatography: Characterization of protein binding and selectivity enhancement through mobile phase modulators

Leslie S. Wolfe, Cartney P Barringer, Sigma S. Mostafa et al. · Journal of Chromatography A · 2014 · 57 citations

, , +17

Multimodal chromatography: debottlenecking the downstream processing of monoclonal antibodies

Inês F. Pinto, M. Raquel Aires‐Barros, Ana M. Azevedo · Pharmaceutical Bioprocessing · 2015 · 55 citations · Full text

, , +17

Investigation of protein binding affinity in multimodal chromatographic systems using a homologous protein library

Wai Keen Chung, Ying Hou, Melissa Holstein et al. · Journal of Chromatography A · 2009 · 54 citations

, , +13

Investigation of protein selectivity in multimodal chromatography using <i>in silico</i> designed Fab fragment variants

Hanne Sophie Karkov, Berit Olsen Krogh, James Woo et al. · Biotechnology and Bioengineering · 2015 · 48 citations

, , +17

1–5 of 28

Authors

139

  1. AM
    Ana M. Azevedo

    Institute for Biotechnology and Bioengineering, Portugal

    4 publications · 128 citations

    5

    h-index

  2. SM
    Steven M. Cramer

    Rensselaer Polytechnic Institute, United States

    4 publications · 205 citations

    4

    h-index

  3. AŠ
    Aleš Štrancar

    BIA Separations (Slovenia), Slovenia

    3 publications · 83 citations

    3

    h-index

  4. DJ
    David J. Roush

    Merck & Co., Inc., Rahway, NJ, USA (United States), United States

    3 publications · 93 citations

    3

    h-index

  5. AR
    A. Rita Silva-Santos

    University of Lisbon, Portugal

    2 publications · 38 citations

    3

    h-index

1–5 of 139

Institutions

46

  1. Rensselaer Polytechnic Institute

    Troy, United States

    5 h-index

    20 publications

    1.1K citations

  2. Institute for Biotechnology and Bioengineering

    Lisbon, Portugal

    4 h-index

    12 publications

    271 citations

  3. BIA Separations (Slovenia)

    Ljubljana, Slovenia

    3 h-index

    24 publications

    664 citations

  4. University of Lisbon

    Lisbon, Portugal

    3 h-index

    9 publications

    166 citations

  5. Merck & Co., Inc., Rahway, NJ, USA (United States)

    Rahway, United States

    3 h-index

    12 publications

    335 citations

  6. City of Hope

    Lancaster, United States

    1 h-index

    1 publications

    20 citations

  7. Fujian Provincial Cancer Hospital

    Fuzhou, China

    1 h-index

    3 publications

    96 citations

  8. Digital Research Alliance of Canada

    Ottawa, Canada

    1 h-index

    1 publications

    46 citations

1–8 of 46

Venues

  1. Journal of Chromatography A

    9 publications · 342 citations

    9

    h-index

  2. Separation and Purification Technology

    4 publications · 84 citations

    4

    h-index

  3. Pharmaceutical Bioprocessing

    1 publications · 55 citations

    1

    h-index

  4. Biotechnology Progress

    1 publications · 43 citations

    1

    h-index

  5. Journal of Biophotonics

    1 publications · 32 citations

    1

    h-index

1–5