Concepedia

Multi-state Binding Models

Multi-State Binding Models is a mathematical framework that describes ligand binding to biomolecules by accounting for multiple conformational states and their interconversions, distinguishing it from classical models through its explicit representation of dynamic equilibria among discrete functional states.

24

Publications

1.6K

Citations

69

Authors

43

Institutions

Publications per year

2017–2026

2

Parents

Publications

24

The two-state model of receptor activation

Paul Leff · Trends in Pharmacological Sciences · 1995 · 505 citations

, , +14

Second Sialic Acid Binding Site in Newcastle Disease Virus Hemagglutinin-Neuraminidase: Implications for Fusion

Viatcheslav Zaitsev, Mark von Itzstein, Darrin R. Groves et al. · Journal of Virology · 2004 · 205 citations · Full text

, , +17

Crystal structure of the λ repressor and a model for pairwise cooperative operator binding

Steven E. Stayrook, Peera Jaru-Ampornpan, Jenny Ni et al. · Nature · 2008 · 108 citations

, , +15

Mathematical Modeling Suggests Cooperative Interactions between a Disordered Polyvalent Ligand and a Single Receptor Site

Peter S. Klein, Tony Pawson, Mike Tyers · Current Biology · 2003 · 101 citations · Full text

, , +14

NMR line shapes and multi-state binding equilibria

Evgenii L. Kovrigin · Journal of Biomolecular NMR · 2012 · 87 citations

, , +6

1–5 of 24

Authors

69

  1. AP
    Allen P. Minton

    National Institute of Diabetes and Digestive and Kidney Diseases, United States

    2 publications · 94 citations

    2

    h-index

  2. PL
    Paul Leff

    Loughborough University, United Kingdom

    2 publications · 564 citations

    2

    h-index

  3. EL
    Evgenii L. Kovrigin

    Marquette University, United States

    2 publications · 104 citations

    2

    h-index

  4. MI
    Melanie I. Stefan

    European Bioinformatics Institute, United Kingdom

    1 publications · 20 citations

    1

    h-index

  5. MV
    Mark von Itzstein

    Griffith University, Australia

    1 publications · 205 citations

    1

    h-index

1–5 of 69

Institutions

43

  1. Loughborough University

    Loughborough, United Kingdom

    3 h-index

    7 publications

    809 citations

  2. University of Pennsylvania

    Philadelphia, United States

    3 h-index

    7 publications

    553 citations

  3. National Institutes of Health

    Bethesda, United States

    3 h-index

    3 publications

    164 citations

  4. National Institute of Arthritis and Musculoskeletal and Skin Diseases

    Bethesda, United States

    2 h-index

    2 publications

    94 citations

  5. Marquette University

    Milwaukee, United States

    2 h-index

    3 publications

    121 citations

  6. University of Amsterdam

    Amsterdam, The Netherlands

    1 h-index

    1 publications

    28 citations

  7. The University of Osaka

    Osaka, Japan

    1 h-index

    3 publications

    51 citations

  8. Urbana University

    Urbana, United States

    1 h-index

    1 publications

    19 citations

1–8 of 43

Venues

  1. Journal of Molecular Biology

    JMB · 2 publications · 83 citations

    2

    h-index

  2. Trends in Pharmacological Sciences

    2 publications · 564 citations

    2

    h-index

  3. Journal of Biomolecular NMR

    2 publications · 104 citations

    2

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 2 publications · 93 citations

    2

    h-index

  5. Science

    1 publications · 11 citations

    1

    h-index

1–5