Concepedia

Multi-arm Multi-stage Trials

Multi-Arm Multi-Stage Trials is a clinical trial design framework that allows for the simultaneous evaluation of multiple experimental treatments against a common control in a staged manner, with pre-specified interim analyses enabling early stopping for futility, efficacy, or arm dropping, thereby improving efficiency and resource allocation compared to traditional separate trials.

67

Publications

4.5K

Citations

482

Authors

241

Institutions

Publications per year

2017–2026

33

Variants

Mams Trials

Parents

Publications

67

Survival with Newly Diagnosed Metastatic Prostate Cancer in the “Docetaxel Era”: Data from 917 Patients in the Control Arm of the STAMPEDE Trial (MRC PR08, CRUK/06/019)

Nicholas D. James, Melissa Spears, Noel W. Clarke et al. · European Urology · 2014 · 436 citations · Full text

, , +17

No more ‘business as usual’ with audit and feedback interventions: towards an agenda for a reinvigorated intervention

Noah Ivers, Anne Sales, Heather Colquhoun et al. · Implementation Science · 2014 · 427 citations · Full text

, , +15

Combining different phases in the development of medical treatments within a single trial

Péter Bauer, Meinhard Kieser · Statistics in Medicine · 1999 · 282 citations

, , +16

Adding abiraterone or docetaxel to long-term hormone therapy for prostate cancer: directly randomised data from the STAMPEDE multi-arm, multi-stage platform protocol

Matthew R. Sydes, Melissa Spears, Malcolm D. Mason et al. · Annals of Oncology · 2018 · 250 citations · Full text

, , +17

Flexible trial design in practice - stopping arms for lack-of-benefit and adding research arms mid-trial in STAMPEDE: a multi-arm multi-stage randomized controlled trial

Matthew R. Sydes, Mahesh Parmar, Malcolm D. Mason et al. · Trials · 2012 · 173 citations · Full text

, , +16

1–5 of 67

Authors

482

  1. MP
    Mahesh Parmar

    University College London, United Kingdom

    25 publications · 2K citations

    21

    h-index

  2. MR
    Matthew R. Sydes

    MRC Clinical Trials Unit at UCL, United Kingdom

    14 publications · 1.5K citations

    13

    h-index

  3. ND
    Nicholas D. James

    University of Birmingham, United Kingdom

    12 publications · 1.5K citations

    12

    h-index

  4. PR
    Patrick Royston

    MRC Clinical Trials Unit at UCL, United Kingdom

    9 publications · 720 citations

    9

    h-index

  5. TJ
    Thomas Jaki

    Lancaster University, United Kingdom

    9 publications · 586 citations

    9

    h-index

1–5 of 482

Institutions

241

  1. MRC Clinical Trials Unit at UCL

    London, United Kingdom

    21 h-index

    159 publications

    11.4K citations

  2. University College London

    London, United Kingdom

    19 h-index

    152 publications

    9.6K citations

  3. Lancaster University

    Lancaster, United Kingdom

    10 h-index

    20 publications

    1.3K citations

  4. Institute of Cancer Research

    London, United Kingdom

    10 h-index

    26 publications

    3.1K citations

  5. University of Birmingham

    Birmingham, United Kingdom

    9 h-index

    30 publications

    3K citations

  6. University of Warwick

    Coventry, United Kingdom

    8 h-index

    23 publications

    1K citations

  7. Medical Research Council

    London, United Kingdom

    7 h-index

    26 publications

    2.3K citations

  8. MRC Biostatistics Unit

    Cambridge, United Kingdom

    7 h-index

    10 publications

    585 citations

1–8 of 241

Venues

  1. Trials

    11 publications · 622 citations

    11

    h-index

  2. Statistics in Medicine

    9 publications · 708 citations

    9

    h-index

  3. Clinical Trials

    4 publications · 173 citations

    4

    h-index

  4. Biometrics

    3 publications · 175 citations

    3

    h-index

  5. Contemporary Clinical Trials

    2 publications · 90 citations

    2

    h-index

1–5