Concepedia

Mrna Circularization

mRNA Circularization is a molecular mechanism in eukaryotic translation initiation wherein the 5' cap and 3' poly(A) tail of an mRNA are brought into proximity through interactions between initiation factors and RNA-binding proteins, thereby forming a closed-loop structure that enhances translational efficiency and ribosome recycling.

61

Publications

7.5K

Citations

303

Authors

146

Institutions

Publications per year

2017–2026

24

Variants

Mrna Closed-loop Formation

Parents

Publications

61

Circularization of mRNA by Eukaryotic Translation Initiation Factors

Sandra E. Wells, P. E. Hillner, Ronald D. Vale et al. · Molecular Cell · 1998 · 975 citations · Full text

, , +12

mRNA circularization by METTL3–eIF3h enhances translation and promotes oncogenesis

Junho Choe, Shuibin Lin, Wen Cai Zhang et al. · Nature · 2018 · 797 citations

, , +14

Widespread and Functional RNA Circularization in Localized Prostate Cancer

Sujun Chen, Vincent Huang, Xin Xu et al. · Cell · 2019 · 691 citations · Full text

, , +14

Combinatorial control of <i>Drosophila</i> circular RNA expression by intronic repeats, hnRNPs, and SR proteins

Marianne C. Kramer, Dongming Liang, Deirdre C. Tatomer et al. · Genes & Development · 2015 · 528 citations · Full text

, , +13

The Output of Protein-Coding Genes Shifts to Circular RNAs When the Pre-mRNA Processing Machinery Is Limiting

Dongming Liang, Deirdre C. Tatomer, Z. David Luo et al. · Molecular Cell · 2017 · 464 citations · Full text

, , +16

1–5 of 61

Authors

303

  1. BM
    Barsanjit Mazumder

    Cleveland State University, United States

    4 publications · 323 citations

    4

    h-index

  2. PL
    Paul L. Fox

    Cleveland Clinic, United States

    4 publications · 323 citations

    4

    h-index

  3. JE
    Jeremy E. Wilusz

    University of Pennsylvania, United States

    3 publications · 1.2K citations

    3

    h-index

  4. PS
    Prabha Sampath

    Agency for Science, Technology and Research, Singapore

    3 publications · 261 citations

    3

    h-index

  5. NS
    Nahum Sonenberg

    McGill University, Canada

    3 publications · 240 citations

    3

    h-index

1–5 of 303

Institutions

146

  1. McGill University

    Montreal, Canada

    4 h-index

    11 publications

    798 citations

  2. University of Pennsylvania

    Philadelphia, United States

    3 h-index

    13 publications

    6K citations

  3. Cleveland State University

    Cleveland, United States

    3 h-index

    5 publications

    404 citations

  4. Institute of Protein Research

    Pushchino, Russia

    3 h-index

    11 publications

    710 citations

  5. Sun Yat-sen University

    Guangzhou, China

    2 h-index

    1 publications

    797 citations

  6. University of Colorado Boulder

    Boulder, United States

    2 h-index

    4 publications

    264 citations

  7. Centre National de la Recherche Scientifique

    Paris, France

    2 h-index

    6 publications

    208 citations

  8. New York University

    New York, United States

    2 h-index

    2 publications

    944 citations

1–8 of 146

Venues

  1. Nucleic Acids Research

    9 publications · 627 citations

    10

    h-index

  2. RNA

    6 publications · 719 citations

    6

    h-index

  3. Molecular and Cellular Biology

    MCB · 3 publications · 371 citations

    3

    h-index

  4. Journal of Biological Chemistry

    JBC · 3 publications · 310 citations

    3

    h-index

  5. Nature

    3 publications · 999 citations

    3

    h-index

1–5