MPL Mutations is a somatic genetic alteration in the thrombopoietin receptor gene (MPL) that drives aberrant activation of the JAK-STAT signaling pathway and is implicated in the pathogenesis of certain myeloproliferative neoplasms.
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2017–2026
106
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423
Somatic Mutations of Calreticulin in Myeloproliferative Neoplasms
Thorsten Klampfl, Heinz Gisslinger, Ashot S. Harutyunyan et al. · New England Journal of Medicine · 2013 · 2K citations · Full text
Medicine, Genetics, Hematology +14
Clinical and biological implications of driver mutations in myelodysplastic syndromes
Elli Papaemmanuil, Moritz Gerstung, Luca Malcovati et al. · Blood · 2013 · 1.8K citations
MPLW515L Is a Novel Somatic Activating Mutation in Myelofibrosis with Myeloid Metaplasia
Yana Pikman, Benjamin H. Lee, Thomas Mercher et al. · PLoS Medicine · 2006 · 1.4K citations · Full text
Life Sciences, Genetics, Hematology +14
MPL515 mutations in myeloproliferative and other myeloid disorders: a study of 1182 patients
Animesh Pardanani, Ross L. Levine, Terra L. Lasho et al. · Blood · 2006 · 1K citations · Full text
Life Sciences, Genetics, Hematology +14
Mutations and prognosis in primary myelofibrosis
A. M. Vannucchi, T L Lasho, Paola Guglielmelli et al. · Leukemia · 2013 · 746 citations
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Mayo Clinic
Rochester, United States
30 h-index
201 publications
25.4K citations
Mayo Clinic in Arizona
Scottsdale, United States
28 h-index
206 publications
51.1K citations
Inserm
Paris, France
28 h-index
267 publications
25.1K citations
University of Florence
Florence, Italy
24 h-index
141 publications
25.9K citations
University of Pavia
Pavia, Italy
23 h-index
77 publications
26.5K citations
Istituti di Ricovero e Cura a Carattere Scientifico
Rome, Italy
23 h-index
105 publications
33.9K citations
Harvard University
Cambridge, United States
19 h-index
102 publications
47.6K citations
Institut Gustave Roussy
Villejuif, France
19 h-index
154 publications
14K citations
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- Blood
71 publications · 13.7K citations
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37 publications · 4.9K citations
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- British Journal of Haematology
BJH · 25 publications · 1.5K citations
21
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- American Journal of Hematology
AJH · 24 publications · 1.2K citations
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- Haematologica
18 publications · 833 citations
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