Concepedia

Monobody Engineering

Monobody Engineering is a protein scaffold engineering methodology that involves the rational design and optimization of monobodies—small, stable, single-domain binding proteins derived from the human fibronectin type III domain—as targeted molecular recognition agents distinct from antibody-based technologies.

14

Publications

719

Citations

106

Authors

41

Institutions

Publications per year

2017–2026

5

Parents

Publications

14

High-affinity single-domain binding proteins with a binary-code interface

Akiko Koide, Ryan Gilbreth, Kaori Esaki et al. · Proceedings of the National Academy of Sciences · 2007 · 180 citations · Full text

, , +17

Contributions of CDR3 to VHH Domain Stability and the Design of Monobody Scaffolds for Naive Antibody Libraries

Christopher J. Bond, James C. Marsters, Sachdev S. Sidhu · Journal of Molecular Biology · 2003 · 98 citations

, , +16

Monobodies: Antibody Mimics Based on the Scaffold of the Fibronectin Type III Domain

Akiko Koide, Shohei Koide · Humana Press eBooks · 2006 · 96 citations

, , +17

Exploring the potential of the monobody scaffold: effects of loop elongation on the stability of a fibronectin type III domain

Vincent Batori, Akiko Koide, Shohei Koide · Protein Engineering Design and Selection · 2002 · 85 citations · Full text

, , +17

Development of light-responsive protein binding in the monobody non-immunoglobulin scaffold

César Carrasco‐López, Evan M. Zhao, Agnieszka A. Gil et al. · Nature Communications · 2020 · 59 citations · Full text

, , +11

1–5 of 14

Authors

106

  1. SK
    Shohei Koide

    University of Chicago, United States

    4 publications · 383 citations

    4

    h-index

  2. AK
    Akiko Koide

    University of Chicago, United States

    4 publications · 383 citations

    4

    h-index

  3. SL
    Seandean L. Harwood

    Aarhus University, Denmark

    1 publications · 38 citations

    1

    h-index

  4. DJ
    Daniel J. Shea

    Niigata University, Japan

    1 publications · 15 citations

    1

    h-index

  5. SP
    Sukho Park

    Chonnam National University, South Korea

    1 publications · 31 citations

    1

    h-index

1–5 of 106

Institutions

41

  1. University of Chicago

    Chicago, United States

    3 h-index

    8 publications

    1.2K citations

  2. Discovery Institute

    Seattle, United States

    2 h-index

    4 publications

    80 citations

  3. Ikerbasque

    Bilbao, Spain

    1 h-index

    1 publications

    38 citations

  4. Sanford Burnham Prebys Medical Discovery Institute

    La Jolla, United States

    1 h-index

    2 publications

    56 citations

  5. University of California San Diego

    San Diego, United States

    1 h-index

    6 publications

    168 citations

  6. MRC Laboratory of Molecular Biology

    Cambridge, United Kingdom

    1 h-index

    1 publications

    12 citations

  7. University of Cambridge

    Cambridge, United Kingdom

    1 h-index

    2 publications

    44 citations

  8. Centre National de la Recherche Scientifique

    Paris, France

    1 h-index

    1 publications

    12 citations

1–8 of 41

Venues

  1. Nature Communications

    2 publications · 81 citations

    2

    h-index

  2. Scientific Reports

    2 publications · 53 citations

    2

    h-index

  3. Biochemistry

    1 publications · 27 citations

    1

    h-index

  4. Journal of Biological Chemistry

    JBC · 1 publications · 12 citations

    1

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 1 publications · 180 citations

    1

    h-index

1–5