Concepedia

Molecular Scaffold Modification

Molecular Scaffold Modification is a strategic alteration of the core structural framework of a molecule to enhance its physicochemical properties, particularly solubility, by modifying its underlying ring systems, connectivity, or substituent architecture while preserving or optimizing its biological activity.

141

Publications

5.9K

Citations

824

Authors

258

Institutions

Publications per year

2017–2026

49

Parents

Publications

141

Molecular Scaffolding Strategy with Synergistic Active Centers To Facilitate Electrocatalytic CO<sub>2</sub> Reduction to Hydrocarbon/Alcohol

Yan Jiao, Yao Zheng, Ping Chen et al. · Journal of the American Chemical Society · 2017 · 528 citations

, , +17

CO<sub>2</sub> Incorporation Reaction Using Arynes:  Straightforward Access to Benzoxazinone

Hiroto Yoshida, Hiroyuki Fukushima, Joji Ohshita et al. · Journal of the American Chemical Society · 2006 · 235 citations

, , +9

Processing of Plasmodium falciparum Merozoite Surface Protein MSP1 Activates a Spectrin-Binding Function Enabling Parasite Egress from RBCs

Sujaan Das, Nadine Hertrich, Abigail J. Perrin et al. · Cell Host & Microbe · 2015 · 197 citations · Full text

, , +17

Design, synthesis, and biological characterization of a peptide-mimetic antagonist for a tethered-ligand receptor

Patricia Andrade‐Gordon, Bruce E. Maryanoff, Claudia K. Derian et al. · Proceedings of the National Academy of Sciences · 1999 · 187 citations

, , +17

Assembling OX40 Aptamers on a Molecular Scaffold to Create a Receptor-Activating Aptamer

Claudia M. Dollins, Smita K. Nair, David Boczkowski et al. · Chemistry & Biology · 2008 · 183 citations · Full text

, , +11

1–5 of 141

Authors

824

  1. JK
    Jongmin Kang

    Sejong University, South Korea

    2 publications · 83 citations

    2

    h-index

  2. CT
    Claudiu T. Supuran

    University of Florence, Italy

    2 publications · 69 citations

    2

    h-index

  3. KV
    Koushik Venkatesan

    University of Zurich, Switzerland

    2 publications · 141 citations

    2

    h-index

  4. RS
    R. Saiganesh

    Annamalai University, India

    2 publications · 141 citations

    2

    h-index

  5. OB
    Olivier Blacque

    University of Zurich, Switzerland

    2 publications · 141 citations

    2

    h-index

1–5 of 824

Institutions

258

  1. Chinese Academy of Sciences

    Beijing, China

    6 h-index

    41 publications

    1.5K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    4 h-index

    16 publications

    303 citations

  3. University of Florence

    Florence, Italy

    3 h-index

    20 publications

    801 citations

  4. Shanghai Institute of Materia Medica

    Pudong, China

    3 h-index

    16 publications

    235 citations

  5. University of Zurich

    Zurich, Switzerland

    3 h-index

    9 publications

    592 citations

  6. University of Manchester

    Manchester, United Kingdom

    3 h-index

    9 publications

    418 citations

  7. Friedrich-Alexander-Universität Erlangen-Nürnberg

    Erlangen, Germany

    3 h-index

    11 publications

    425 citations

  8. University of Chinese Academy of Sciences

    Beijing, China

    3 h-index

    10 publications

    174 citations

1–8 of 258

Venues

  1. Angewandte Chemie International Edition

    9 publications · 326 citations

    9

    h-index

  2. Journal of Medicinal Chemistry

    8 publications · 453 citations

    8

    h-index

  3. Tetrahedron Letters

    7 publications · 145 citations

    7

    h-index

  4. The Journal of Organic Chemistry

    JOC · 7 publications · 205 citations

    7

    h-index

  5. European Journal of Organic Chemistry

    5 publications · 85 citations

    5

    h-index

1–5