Concepedia

Molecular Clockwork

Molecular Clockwork is a biological mechanism that constitutes the intrinsic timekeeping system within cells, particularly in the suprachiasmatic nucleus, by means of autoregulatory transcriptional-translational feedback loops involving clock genes and their protein products, thereby generating circadian rhythms at the molecular level.

270

Publications

22.2K

Citations

1.2K

Authors

442

Institutions

Publications per year

2017–2026

80

Variants

Circadian Molecular ClockMolecular Circadian Clock

Parents

Publications

270

Reconstitution of Circadian Oscillation of Cyanobacterial KaiC Phosphorylation in Vitro

Masato Nakajima, Keiko Imai, Hiroshi Ito et al. · Science · 2005 · 1.1K citations

, , +16

A synchronized quorum of genetic clocks

Tal Danino, Octavio Mondragón-Palomino, Lev S. Tsimring et al. · Nature · 2010 · 1K citations

, , +10

Light-Independent Role of CRY1 and CRY2 in the Mammalian Circadian Clock

Edmund A. Griffin, David Staknis, Charles J. Weitz · Science · 1999 · 635 citations

, , +16

The Circadian Gene Per1 Plays an Important Role in Cell Growth and DNA Damage Control in Human Cancer Cells

Sigal Gery, Naoki Komatsu, Lilit Baldjyan et al. · Molecular Cell · 2006 · 627 citations · Full text

, , +17

The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome

Baokun He, Kazunari Nohara, Noheon Park et al. · Cell Metabolism · 2016 · 502 citations · Full text

, , +17

1–5 of 270

Authors

1.2K

  1. TK
    Takao Kondo

    Nagoya University, Japan

    10 publications · 2.3K citations

    10

    h-index

  2. AS
    Alena Sumová

    Czech Academy of Sciences, Czechia

    9 publications · 489 citations

    9

    h-index

  3. MS
    Martin Sládek

    Czech Academy of Sciences, Czechia

    7 publications · 790 citations

    7

    h-index

  4. ZB
    Zdeňka Bendová

    Czech Academy of Sciences, Czechia

    7 publications · 419 citations

    7

    h-index

  5. JE
    Johanna E. Chesham

    MRC Laboratory of Molecular Biology, United Kingdom

    7 publications · 822 citations

    7

    h-index

1–5 of 1.2K

Institutions

442

  1. Nagoya University

    Nagoya, Japan

    14 h-index

    76 publications

    8.1K citations

  2. University of California San Diego

    San Diego, United States

    11 h-index

    29 publications

    5.6K citations

  3. Czech Academy of Sciences

    Prague, Czechia

    10 h-index

    42 publications

    2.1K citations

  4. Czech Academy of Sciences, Institute of Physiology

    Prague, Czechia

    10 h-index

    41 publications

    2.1K citations

  5. The University of Osaka

    Osaka, Japan

    9 h-index

    15 publications

    1.6K citations

  6. Howard Hughes Medical Institute

    Chevy Chase, United States

    8 h-index

    19 publications

    4.1K citations

  7. Vanderbilt University

    Nashville, United States

    8 h-index

    42 publications

    4K citations

  8. Harvard University

    Cambridge, United States

    8 h-index

    21 publications

    4.7K citations

1–8 of 442

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 33 publications · 3.3K citations

    28

    h-index

  2. Science

    14 publications · 3.5K citations

    13

    h-index

  3. Chronobiology International

    10 publications · 412 citations

    10

    h-index

  4. PLoS ONE

    9 publications · 549 citations

    9

    h-index

  5. PubMed

    Repository · 7 publications · 441 citations

    7

    h-index

1–5