Concepedia

Module-based Disease Mechanisms

Module-Based Disease Mechanisms is a theoretical framework in network medicine that identifies and characterizes disease pathways by detecting functionally coherent, interconnected subnetworks (modules) within biological networks, distinguishing it from other approaches by emphasizing the modular organization of molecular interactions underlying complex diseases.

57

Publications

3.5K

Citations

340

Authors

166

Institutions

Publications per year

2017–2026

32

Parents

Publications

57

Clan Genomics and the Complex Architecture of Human Disease

James R. Lupski, John W. Belmont, Eric Boerwinkle et al. · Cell · 2011 · 383 citations · Full text

, , +16

Tissue-specific regulatory circuits reveal variable modular perturbations across complex diseases

Daniel Marbach, David Lamparter, Gerald Quon et al. · Nature Methods · 2016 · 381 citations · Full text

, , +16

dmGWAS: dense module searching for genome-wide association studies in protein–protein interaction networks

Peilin Jia, Siyuan Zheng, Jirong Long et al. · Bioinformatics · 2010 · 291 citations

, , +17

Herb network construction and co-module analysis for uncovering the combination rule of traditional Chinese herbal formulae

Shao Li, Bo Zhang, Duo Jiang et al. · BMC Bioinformatics · 2010 · 284 citations · Full text

, , +14

A disease module in the interactome explains disease heterogeneity, drug response and captures novel pathways and genes in asthma

Amitabh Sharma, Jörg Menche, Chaohua Huang et al. · Human Molecular Genetics · 2015 · 211 citations · Full text

, , +17

1–5 of 57

Authors

340

  1. AB
    Albert-Ĺaszló Barabási

    Northeastern University, United States

    4 publications · 542 citations

    4

    h-index

  2. DB
    David B. Blumenthal

    Technical University of Munich, Germany

    3 publications · 225 citations

    3

    h-index

  3. EK
    Edwin K. Silverman

    Brigham and Women's Hospital, United States

    3 publications · 284 citations

    3

    h-index

  4. RW
    Rui‐Sheng Wang

    Brigham and Women's Hospital, United States

    3 publications · 239 citations

    3

    h-index

  5. AS
    Amitabh Sharma

    Brigham and Women's Hospital, United States

    3 publications · 325 citations

    3

    h-index

1–5 of 340

Institutions

166

  1. Harvard University

    Cambridge, United States

    7 h-index

    42 publications

    4.3K citations

  2. Brigham and Women's Hospital

    Boston, United States

    7 h-index

    42 publications

    4.2K citations

  3. Chinese Academy of Medical Sciences & Peking Union Medical College

    Beijing, China

    5 h-index

    27 publications

    503 citations

  4. Northeastern University

    Boston, United States

    4 h-index

    12 publications

    1.7K citations

  5. Universität Hamburg

    Hamburg, Germany

    4 h-index

    8 publications

    673 citations

  6. University of Southern Denmark

    Odense, Denmark

    3 h-index

    3 publications

    225 citations

  7. Linköping University

    Linköping, Sweden

    3 h-index

    13 publications

    986 citations

  8. Chinese Academy of Sciences

    Beijing, China

    3 h-index

    4 publications

    146 citations

1–8 of 166

Venues

  1. Scientific Reports

    6 publications · 261 citations

    6

    h-index

  2. Bioinformatics

    5 publications · 398 citations

    5

    h-index

  3. BMC Bioinformatics

    2 publications · 324 citations

    2

    h-index

  4. BMC Genomics

    2 publications · 59 citations

    2

    h-index

  5. Genome Medicine

    2 publications · 220 citations

    2

    h-index

1–5