Concepedia

Module Swapping

Module Swapping is a dynamic reconfiguration strategy in combinatorial biosynthesis that involves the systematic substitution of functional genetic or metabolic modules within a biosynthetic pathway to generate structural diversity in target compounds.

14

Publications

792

Citations

83

Authors

23

Institutions

Publications per year

2017–2026

3

Parents

Publications

14

Synthetic shuffling expands functional protein diversity by allowing amino acids to recombine independently

Jon E. Ness, Seran Kim, Andrea Gottman et al. · Nature Biotechnology · 2002 · 201 citations

, , +11

Quantitative Analysis of the Relative Contributions of Donor Acyl Carrier Proteins, Acceptor Ketosynthases, and Linker Regions to Intermodular Transfer of Intermediates in Hybrid Polyketide Synthases

Nicholas Wu, David E. Cane, Chaitan Khosla · Biochemistry · 2002 · 130 citations

, , +15

Structure of a Bacteriophytochrome and Light-Stimulated Protomer Swapping with a Gene Repressor

Dom Bellini, Miroslav Z. Papiz · Structure · 2012 · 102 citations · Full text

, , +8

A Polylinker Approach to Reductive Loop Swaps in Modular Polyketide Synthases

Laurenz Kellenberger, Ian S. Galloway, Guido Sauter et al. · ChemBioChem · 2008 · 65 citations

, , +15

Structure and Mechanism of the Lipooligosaccharide Sialyltransferase from Neisseria meningitidis

Leo Lin, Bojana Rakić, Cecilia Chiu et al. · Journal of Biological Chemistry · 2011 · 48 citations · Full text

, , +14

1–5 of 14

Authors

83

  1. SL
    Shih-Han Lin

    China Agricultural University, China

    1 publications · 19 citations

    1

    h-index

  2. TV
    Torben V. Borchert

    Novozymes (Denmark), Denmark

    1 publications · 201 citations

    1

    h-index

  3. OC
    Orlando Crescenzi

    University of Naples Federico II, Italy

    1 publications · 19 citations

    1

    h-index

  4. SG
    Sridhar Govindarajan

    ATUM (United States), United States

    1 publications · 201 citations

    1

    h-index

  5. FA
    Francesca Avitabile

    Istituto di Chimica Biomolecolare, Italy

    1 publications · 19 citations

    1

    h-index

1–5 of 83

Institutions

23

  1. Northeast Electric Power University

    Jilin City, China

    1 h-index

    2 publications

    50 citations

  2. The University of Texas at Tyler

    Tyler, United States

    1 h-index

    6 publications

    228 citations

  3. University of British Columbia

    Vancouver, Canada

    1 h-index

    6 publications

    288 citations

  4. Novozymes (Denmark)

    Copenhagen, Denmark

    1 h-index

    1 publications

    201 citations

  5. University of Cambridge

    Cambridge, United Kingdom

    1 h-index

    8 publications

    520 citations

  6. Academia Sinica

    Taipei, Taiwan

    1 h-index

    1 publications

    19 citations

  7. Utah State University

    Logan, United States

    1 h-index

    4 publications

    100 citations

  8. Maxygen (United States)

    Redwood City, United States

    1 h-index

    8 publications

    1.6K citations

1–8 of 23

Venues

  1. Structure

    1 publications · 102 citations

    1

    h-index

  2. Biochemistry

    1 publications · 130 citations

    1

    h-index

  3. 1

    h-index

  4. ChemBioChem

    1 publications · 65 citations

    1

    h-index

  5. Nature Biotechnology

    1 publications · 201 citations

    1

    h-index

1–5