Concepedia

Mixture-based Synthesis

Mixture-Based Synthesis is a parallel synthesis strategy in combinatorial chemistry wherein multiple building blocks are simultaneously coupled in a single reaction vessel to generate a molecular library as a mixture, distinguished from discrete synthesis approaches by its pooled execution and subsequent deconvolution or direct screening of components.

35

Publications

1.9K

Citations

94

Authors

31

Institutions

Publications per year

2017–2026

4

Parents

Publications

35

Fluorous Mixture Synthesis: A Fluorous-Tagging Strategy for the Synthesis and Separation of Mixtures of Organic Compounds

Zhiyong Luo, Qisheng Zhang, Yoji Oderaotoshi et al. · Science · 2001 · 298 citations

, , +14

Solution-Phase Preparation of a 560-Compound Library of Individual Pure Mappicine Analogues by Fluorous Mixture Synthesis

Wei Zhang, Zhiyong Luo, Christine Hiu‐Tung Chen et al. · Journal of the American Chemical Society · 2002 · 132 citations

, , +17

OptCAMD: An optimization-based framework and tool for molecular and mixture product design

Qilei Liu, Lei Zhang, Linlin Liu et al. · Computers & Chemical Engineering · 2019 · 116 citations

, , +13

Advances in the use of synthetic combinatorial chemistry: Mixture-based libraries

Clemencia Pinilla, Jon R. Appel, Eva Borràs et al. · Nature Medicine · 2003 · 101 citations

, , +13

Fluorous Mixture Synthesis of Stereoisomer Libraries:  Total Syntheses of (+)-Murisolin and Fifteen Diastereoisomers

Qisheng Zhang, Hejun Lu, Cyrille Richard et al. · Journal of the American Chemical Society · 2003 · 94 citations

, , +12

1–5 of 35

Authors

94

  1. DP
    Dennis P. Curran

    University of Pittsburgh, United States

    18 publications · 1.1K citations

    17

    h-index

  2. WZ
    Wei Zhang

    University of Massachusetts Boston, United States

    4 publications · 245 citations

    4

    h-index

  3. QZ
    Qisheng Zhang

    University of North Carolina at Chapel Hill, United States

    3 publications · 474 citations

    3

    h-index

  4. CS
    Craig S. Wilcox

    University of Pittsburgh, United States

    3 publications · 85 citations

    3

    h-index

  5. BS
    Bin Sui

    The University of Osaka, Japan

    3 publications · 90 citations

    3

    h-index

1–5 of 94

Institutions

31

  1. University of Pittsburgh

    Pittsburgh, United States

    19 h-index

    74 publications

    4.5K citations

  2. Fluorous Technologies (United States)

    Pittsburgh, United States

    5 h-index

    12 publications

    1.2K citations

  3. Centre National de la Recherche Scientifique

    Paris, France

    2 h-index

    6 publications

    142 citations

  4. Bayer (Germany)

    Leverkusen, Germany

    2 h-index

    2 publications

    60 citations

  5. Southwest Bahia State University

    Vitória da Conquista, Brazil

    1 h-index

    5 publications

    375 citations

  6. Meijo University

    Nagoya, Japan

    1 h-index

    6 publications

    72 citations

  7. Institut de Chimie Moléculaire et des Matériaux d'Orsay

    Orsay, France

    1 h-index

    5 publications

    120 citations

  8. Boston University

    Boston, United States

    1 h-index

    2 publications

    42 citations

1–8 of 31

Venues

  1. The Journal of Organic Chemistry

    JOC · 6 publications · 234 citations

    6

    h-index

  2. Journal of the American Chemical Society

    JACS · 5 publications · 357 citations

    5

    h-index

  3. Journal of Combinatorial Chemistry

    3 publications · 107 citations

    3

    h-index

  4. Tetrahedron

    2 publications · 51 citations

    2

    h-index

  5. Tetrahedron Letters

    2 publications · 30 citations

    2

    h-index

1–5