Concepedia

Mitochondrial Base Conversion

Mitochondrial Base Conversion is a genome editing technique that enables the targeted alteration of individual nucleotide bases within mitochondrial DNA without inducing double-strand breaks, thereby facilitating precise point mutations in the mitochondrial genome.

12

Publications

974

Citations

70

Authors

19

Institutions

Publications per year

2017–2026

9

Parents

Publications

12

Targeted A-to-G base editing in human mitochondrial DNA with programmable deaminases

Sung-Ik Cho, Seonghyun Lee, Young Geun Mok et al. · Cell · 2022 · 250 citations

, , +13

Mitochondrial DNA editing in mice with DddA-TALE fusion deaminases

Hyunji Lee, Seonghyun Lee, Gayoung Baek et al. · Nature Communications · 2021 · 157 citations · Full text

, , +15

Mitochondrial base editor induces substantial nuclear off-target mutations

Zhi‐Xin Lei, Haowei Meng, Lulu Liu et al. · Nature · 2022 · 120 citations

, , +13

Precision mitochondrial DNA editing with high-fidelity DddA-derived base editors

Seonghyun Lee, Hyunji Lee, Gayoung Baek et al. · Nature Biotechnology · 2022 · 99 citations · Full text

, , +14

Precision modeling of mitochondrial diseases in zebrafish via DdCBE-mediated mtDNA base editing

Jiayin Guo, Xue Zhang, Xiaoxu Chen et al. · Cell Discovery · 2021 · 90 citations · Full text

, , +16

1–5 of 12

Authors

70

  1. JK
    Jin‐Soo Kim

    Seoul National University, South Korea

    4 publications · 555 citations

    4

    h-index

  2. BS
    Bin Shen

    Nanjing Medical University, China

    3 publications · 190 citations

    3

    h-index

  3. SL
    Seonghyun Lee

    Sogang University, South Korea

    3 publications · 506 citations

    3

    h-index

  4. XQ
    Xuezhen Qian

    Nanjing Maternity and Child Health Care Hospital, China

    3 publications · 190 citations

    3

    h-index

  5. HS
    Haifeng Sun

    Chinese Academy of Sciences, China

    3 publications · 190 citations

    3

    h-index

1–5 of 70

Institutions

19

  1. Institute for Basic Science

    Daejeon, South Korea

    4 h-index

    25 publications

    3.7K citations

  2. Nanjing Maternity and Child Health Care Hospital

    Nanjing, China

    3 h-index

    14 publications

    524 citations

  3. Nanjing Medical University

    Nanjing, China

    3 h-index

    32 publications

    2K citations

  4. Seoul National University

    Seoul, South Korea

    3 h-index

    10 publications

    1.5K citations

  5. Center for Life Sciences

    Beijing, China

    2 h-index

    9 publications

    903 citations

  6. Peking University

    Beijing, China

    2 h-index

    24 publications

    2.1K citations

  7. Soochow University

    Suzhou, China

    2 h-index

    10 publications

    692 citations

  8. Nanjing University

    Nanjing, China

    1 h-index

    2 publications

    180 citations

1–8 of 19

Venues

  1. Nature Communications

    4 publications · 293 citations

    4

    h-index

  2. Nature

    1 publications · 120 citations

    1

    h-index

  3. Genes

    1 publications · 16 citations

    1

    h-index

  4. Cell

    1 publications · 250 citations

    1

    h-index

  5. Toxicology Letters

    1 publications · 15 citations

    1

    h-index

1–5