Concepedia

Mirror-image Aptamers

Mirror-Image Aptamers is a class of nucleic acid aptamers composed of L-enantiomeric nucleotides that are stereoisomeric counterparts of natural D-aptamers, enabling resistance to nuclease degradation and facilitating target binding through mirror-image recognition.

15

Publications

1.1K

Citations

70

Authors

29

Institutions

Publications per year

2017–2026

5

Variants

Spiegelmers

Parents

Publications

15

Bioactive and nuclease-resistant <scp>l</scp> -DNA ligand of vasopressin

Kelly P. Williams, Xiaohong Liu, Ton N. Schumacher et al. · Proceedings of the National Academy of Sciences · 1997 · 217 citations · Full text

, , +14

Development of an automated in vitro selection protocol to obtain RNA-based aptamers: identification of a biostable substance P antagonist

Dirk Eulberg · Nucleic Acids Research · 2005 · 139 citations · Full text

, , +17

Short bioactive Spiegelmers to migraine-associated calcitonin gene-related peptide rapidly identified by a novel approach: Tailored-SELEX

Axel Vater · Nucleic Acids Research · 2003 · 136 citations · Full text

, , +17

Crystal structure of a mirror-image L-RNA aptamer (Spiegelmer) in complex with the natural L-protein target CCL2

Dominik Oberthür, John Achenbach, Azat Gabdulkhakov et al. · Nature Communications · 2015 · 98 citations · Full text

, , +17

Toward third-generation aptamers: Spiegelmers and their therapeutic prospects.

Axel Vater · PubMed · 2003 · 90 citations

, , +16

1–5 of 15

Authors

70

  1. AV
    Axel Vater

    Noxxon Pharma (Germany), Germany

    3 publications · 281 citations

    3

    h-index

  2. EW
    Eliza Wyszko

    Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poland

    2 publications · 32 citations

    2

    h-index

  3. KB
    Klaus Buchner

    Freie Universität Berlin, Germany

    2 publications · 153 citations

    2

    h-index

  4. JB
    Jan Barciszewski

    Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poland

    2 publications · 32 citations

    2

    h-index

  5. CM
    Christian Maasch

    Noxxon Pharma (Germany), Germany

    2 publications · 153 citations

    2

    h-index

1–5 of 70

Institutions

29

  1. Noxxon Pharma (Germany)

    Berlin, Germany

    6 h-index

    19 publications

    1.3K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    2 h-index

    10 publications

    408 citations

  3. Center for Life Sciences

    Beijing, China

    2 h-index

    13 publications

    881 citations

  4. Tsinghua University

    Beijing, China

    2 h-index

    12 publications

    814 citations

  5. Institute of Bioorganic Chemistry, Polish Academy of Sciences

    Poznan, Poland

    2 h-index

    7 publications

    109 citations

  6. Texas A&M University

    College Station, United States

    2 h-index

    4 publications

    186 citations

  7. Freie Universität Berlin

    Berlin, Germany

    2 h-index

    3 publications

    45 citations

  8. Charité - Universitätsmedizin Berlin

    Berlin, Germany

    2 h-index

    2 publications

    74 citations

1–8 of 29

Venues

  1. Nucleic Acids Research

    2 publications · 275 citations

    2

    h-index

  2. PLoS ONE

    2 publications · 32 citations

    2

    h-index

  3. Nature Communications

    1 publications · 98 citations

    1

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 1 publications · 217 citations

    1

    h-index

  5. Nature Biotechnology

    1 publications · 67 citations

    1

    h-index

1–5