Concepedia

Miniprotein Design

Miniprotein Design is a computational and experimental framework within protein design modeling that focuses on the de novo creation of small, stable, and functionally specific protein structures, typically under 50 amino acids, distinguished by their minimized size, enhanced biophysical properties, and potential for precise molecular recognition and therapeutic application.

63

Publications

3K

Citations

410

Authors

155

Institutions

Publications per year

2017–2026

17

Parents

Publications

63

Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo

Angelika Böttger, Volker Böttger, Alison Sparks et al. · Current Biology · 1997 · 363 citations · Full text

, , +11

Chiral Protein Supraparticles for Tumor Suppression and Synergistic Immunotherapy: An Enabling Strategy for Bioactive Supramolecular Chirality Construction

Jin Yan, Yu Yao, Siqi Yan et al. · Nano Letters · 2020 · 208 citations

, , +17

Rational engineering of a miniprotein that reproduces the core of the CD4 site interacting with HIV-1 envelope glycoprotein

Claudio Vita, Jean Vizzavona, Sandrine Rochette et al. · Proceedings of the National Academy of Sciences · 1999 · 156 citations · Full text

, , +16

DAPK-1 Binding to a Linear Peptide Motif in MAP1B Stimulates Autophagy and Membrane Blebbing

Benjamin J. Harrison, Michaela Kraus, Lindsay Burch et al. · Journal of Biological Chemistry · 2008 · 135 citations · Full text

, , +17

Multivalent designed proteins neutralize SARS-CoV-2 variants of concern and confer protection against infection in mice

Andrew C. Hunt, James Brett Case, Young‐Jun Park et al. · Science Translational Medicine · 2022 · 118 citations · Full text

, , +15

1–5 of 63

Authors

410

  1. LC
    Lauren Carter

    University of Washington, United States

    4 publications · 225 citations

    4

    h-index

  2. LS
    Lance Stewart

    University of Washington, United States

    4 publications · 225 citations

    4

    h-index

  3. DB
    David Baker

    University of Washington, United States

    4 publications · 225 citations

    4

    h-index

  4. AS
    Alanna Schepartz

    Yale University, United States

    3 publications · 138 citations

    3

    h-index

  5. RR
    Rashmi Ravichandran

    University of Washington, United States

    3 publications · 181 citations

    3

    h-index

1–5 of 410

Institutions

155

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    6 h-index

    22 publications

    1.4K citations

  2. University of Washington

    Seattle, United States

    4 h-index

    94 publications

    5.5K citations

  3. Commissariat à l'Énergie Atomique et aux Énergies Alternatives

    Paris, France

    3 h-index

    18 publications

    1.8K citations

  4. Universidade de Santiago de Compostela

    Santiago de Compostela, Spain

    3 h-index

    14 publications

    254 citations

  5. Northwestern University

    Evanston, United States

    3 h-index

    9 publications

    589 citations

  6. Max Planck Society

    Munich, Germany

    3 h-index

    10 publications

    345 citations

  7. Yale University

    New Haven, United States

    3 h-index

    5 publications

    264 citations

  8. University of Göttingen

    Göttingen, Germany

    3 h-index

    8 publications

    418 citations

1–8 of 155

Venues

  1. Angewandte Chemie International Edition

    4 publications · 214 citations

    4

    h-index

  2. Chemical Communications

    ChemComm · 4 publications · 71 citations

    4

    h-index

  3. Journal of Molecular Biology

    JMB · 3 publications · 148 citations

    3

    h-index

  4. Nature Communications

    3 publications · 112 citations

    3

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 3 publications · 271 citations

    3

    h-index

1–5