Concepedia

Microsomal Protein Binding

Microsomal Protein Binding is a biochemical interaction phenomenon in which xenobiotics reversibly associate with proteins present in hepatic microsomal fractions, primarily cytochrome P450 enzymes and other drug-metabolizing proteins, thereby influencing the compound's free concentration and metabolic stability.

416

Publications

19.6K

Citations

1.3K

Authors

379

Institutions

Publications per year

2017–2026

2

Parents

Publications

416

Acetaminophen-induced hepatic necrosis. 3. Cytochrome P-450-mediated covalent binding in vitro.

William Z. Potter, Dawn C. Davis, John R. Mitchell et al. · PubMed · 1973 · 501 citations

, , +17

A Form of Cytochrome <i>b</i> <sub>5</sub> That Contains an Additional Hydrophobic Sequence of 40 Amino Acid Residues

Lawrence Spatz, Philipp Strittmatter · Proceedings of the National Academy of Sciences · 1971 · 454 citations · Full text

, , +14

Phosphorylation of a 22,000-dalton component of the cardiac sarcoplasmic reticulum by adenosine 3':5'-monophosphate-dependent protein kinase.

Michihiko Tada, M A Kirchberger, AM Katz · Journal of Biological Chemistry · 1975 · 434 citations · Full text

, , +15

A microsome-dependent binding of benzo[a]pyrene to DNA.

Harry V. Gelboin · PubMed · 1969 · 327 citations

, , +10

Differential effects of phenobarbitone and 3-methylcholanthrene induction on the hepatic microsomal metabolism and cytochrome P-450-binding of phenoxazone and a homologous series of its n-alkyl ethers (alkoxyresorufins)

M.D. Burke, Richard T. Mayer · Chemico-Biological Interactions · 1983 · 327 citations

, , +16

1–5 of 416

Authors

1.3K

  1. HK
    H. Kappus

    University of Tübingen, Germany

    7 publications · 285 citations

    7

    h-index

  2. HM
    Hermann M. Bolt

    TU Dortmund University, Germany

    6 publications · 235 citations

    6

    h-index

  3. HL
    Hira L. Gurtoo

    Roswell Park Comprehensive Cancer Center, United States

    5 publications · 198 citations

    5

    h-index

  4. SN
    Shizuo Narimatsu

    Okayama University, Japan

    5 publications · 84 citations

    5

    h-index

  5. VK
    Virginia Kubic

    University of Minnesota, United States

    5 publications · 279 citations

    5

    h-index

1–5 of 1.3K

Institutions

379

  1. University of Tübingen

    Tübingen, Germany

    9 h-index

    20 publications

    1.2K citations

  2. National Institutes of Health

    Bethesda, United States

    8 h-index

    31 publications

    2.5K citations

  3. Chiba University

    Chiba, Japan

    7 h-index

    33 publications

    590 citations

  4. Inserm

    Paris, France

    7 h-index

    32 publications

    834 citations

  5. University of Toronto

    Toronto, Canada

    6 h-index

    25 publications

    445 citations

  6. University of Washington

    Seattle, United States

    5 h-index

    19 publications

    846 citations

  7. National Cancer Institute

    Bethesda, United States

    5 h-index

    14 publications

    631 citations

  8. Johannes Gutenberg University Mainz

    Mainz, Germany

    5 h-index

    11 publications

    424 citations

1–8 of 379

Venues

  1. Journal of Biological Chemistry

    JBC · 31 publications · 2.8K citations

    26

    h-index

  2. PubMed

    Repository · 48 publications · 2.9K citations

    25

    h-index

  3. Drug Metabolism and Disposition

    30 publications · 1.2K citations

    22

    h-index

  4. Biochemical Pharmacology

    24 publications · 771 citations

    17

    h-index

  5. 15

    h-index

1–5