Concepedia

Microhomology Usage

Microhomology Usage is a molecular repair mechanism that belongs to the class of DNA double-strand break repair pathways and is distinguished by the reliance on short, directly homologous nucleotide sequences—typically 2–20 base pairs in length—flanking the break site to facilitate error-prone end joining through annealing and ligation, thereby enabling genomic rejoining without a homologous template.

15

Publications

1.2K

Citations

89

Authors

37

Institutions

Publications per year

2017–2026

9

Parents

Publications

15

EuPaGDT: a web tool tailored to design CRISPR guide RNAs for eukaryotic pathogens

Duo Peng, Rick L. Tarleton · Microbial Genomics · 2015 · 326 citations · Full text

, , +16

Massively parallel profiling and predictive modeling of the outcomes of CRISPR/Cas9-mediated double-strand break repair

Wei Chen, Aaron McKenna, Jacob Schreiber et al. · Nucleic Acids Research · 2019 · 239 citations · Full text

, , +16

Different types of V(D)J recombination and end-joining defects in DNA double-strand break repair mutant mammalian cells

Nicole S. Verkaik, Rebecca E. E. Esveldt–van Lange, Diana van Heemst et al. · European Journal of Immunology · 2002 · 186 citations

, , +17

C-NHEJ without indels is robust and requires synergistic function of distinct XLF domains

Ragini Bhargava, Manbir Sandhu, Sanychen Muk et al. · Nature Communications · 2018 · 106 citations · Full text

, , +15

Highly Frequent Frameshift DNA Synthesis by Human DNA Polymerase μ

Yanbin Zhang, Xiaohua Wu, Fenghua Yuan et al. · Molecular and Cellular Biology · 2001 · 84 citations

, , +13

1–5 of 15

Authors

89

  1. VA
    Vikram Agarwal

    Howard Hughes Medical Institute, United States

    2 publications · 265 citations

    2

    h-index

  2. JS
    Jacob Schreiber

    University of Washington, United States

    2 publications · 265 citations

    2

    h-index

  3. JS
    Jay Shendure

    University of Washington, United States

    2 publications · 265 citations

    2

    h-index

  4. WS
    William Stafford Noble

    University of Washington, United States

    2 publications · 265 citations

    2

    h-index

  5. XC
    Xiongfong Chen

    National Institutes of Health, United States

    2 publications · 47 citations

    2

    h-index

1–5 of 89

Institutions

37

  1. Brotman Baty Institute

    Seattle, United States

    2 h-index

    2 publications

    265 citations

  2. University of Washington

    Seattle, United States

    2 h-index

    14 publications

    1.9K citations

  3. Howard Hughes Medical Institute

    Chevy Chase, United States

    2 h-index

    2 publications

    265 citations

  4. Center for Cancer Research

    Bethesda, United States

    1 h-index

    5 publications

    135 citations

  5. Kansas State University

    Manhattan, United States

    1 h-index

    7 publications

    287 citations

  6. Cancer Genetics (United States)

    Rutherford, United States

    1 h-index

    3 publications

    318 citations

  7. University of Delaware

    Newark, United States

    1 h-index

    2 publications

    32 citations

  8. Erasmus University Rotterdam

    Rotterdam, The Netherlands

    1 h-index

    5 publications

    930 citations

1–8 of 37

Venues

  1. Nucleic Acids Research

    5 publications · 332 citations

    5

    h-index

  2. Nature Communications

    2 publications · 147 citations

    2

    h-index

  3. Genetics

    1 publications · 29 citations

    1

    h-index

  4. The CRISPR Journal

    1 publications · 16 citations

    1

    h-index

  5. Microbial Genomics

    MGen · 1 publications · 326 citations

    1

    h-index

1–5