Concepedia

Microglial Synaptic Pruning

Microglial Synaptic Pruning is a biological process in which microglia, as resident immune cells of the central nervous system, selectively eliminate redundant or weaker synaptic connections during neural circuit refinement, thereby contributing to experience-dependent plasticity and optimal brain connectivity.

63

Publications

11.2K

Citations

500

Authors

167

Institutions

Publications per year

2017–2026

55

Parents

Publications

63

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

Rosa Chiara Paolicelli, Giulia Bolasco, Francesca Pagani et al. · Science · 2011 · 4.2K citations

, , +17

Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning

Carl M. Sellgren, Jessica Gracias, Bradley Watmuff et al. · Nature Neuroscience · 2019 · 828 citations

, , +16

Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction

Laetitia Weinhard, Giulia Di Bartolomei, Giulia Bolasco et al. · Nature Communications · 2018 · 801 citations · Full text

, , +17

CD47 Protects Synapses from Excess Microglia-Mediated Pruning during Development

Emily K. Lehrman, Daniel K. Wilton, Elizabeth Y. Litvina et al. · Neuron · 2018 · 474 citations · Full text

, , +12

Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia

Nicole Scott‐Hewitt, Fabio Perrucci, Raffaella Morini et al. · The EMBO Journal · 2020 · 422 citations · Full text

, , +17

1–5 of 63

Authors

500

  1. BS
    Beth Stevens

    Boston Children's Hospital, United States

    4 publications · 1.3K citations

    4

    h-index

  2. RX
    Ranjie Xu

    Rutgers, The State University of New Jersey, United States

    4 publications · 303 citations

    4

    h-index

  3. RC
    Rosa Chiara Paolicelli

    University of Lausanne, Switzerland

    3 publications · 4.3K citations

    3

    h-index

  4. GB
    Giulia Bolasco

    European Molecular Biology Laboratory, Italy

    3 publications · 5.1K citations

    3

    h-index

  5. CT
    Cornelius T. Gross

    European Molecular Biology Laboratory, Italy

    3 publications · 5.1K citations

    3

    h-index

1–5 of 500

Institutions

167

  1. Boston Children's Hospital

    Boston, United States

    5 h-index

    31 publications

    10K citations

  2. Harvard University

    Cambridge, United States

    5 h-index

    37 publications

    17.6K citations

  3. University of California, Irvine

    Irvine, United States

    4 h-index

    29 publications

    2.3K citations

  4. Université Laval

    Québec, Canada

    4 h-index

    7 publications

    622 citations

  5. Broad Institute

    Cambridge, United States

    4 h-index

    8 publications

    2.4K citations

  6. European Molecular Biology Laboratory

    Monterotondo, Italy

    3 h-index

    22 publications

    32.3K citations

  7. Neuroscience Institute

    Pisa, Italy

    3 h-index

    3 publications

    4.7K citations

  8. Cleveland Clinic Lerner College of Medicine

    Cleveland, United States

    3 h-index

    10 publications

    645 citations

1–8 of 167

Venues

  1. Journal of Neuroinflammation

    JNI · 4 publications · 223 citations

    4

    h-index

  2. Cell Reports

    4 publications · 410 citations

    4

    h-index

  3. Molecular Psychiatry

    3 publications · 300 citations

    3

    h-index

  4. Frontiers in Cellular Neuroscience

    3 publications · 248 citations

    3

    h-index

  5. bioRxiv (Cold Spring Harbor Laboratory)

    Repository · 3 publications · 109 citations

    3

    h-index

1–5