Concepedia

Mhc-driven Balancing Selection

MHC-Driven Balancing Selection is a form of pathogen-mediated balancing selection in which allelic diversity at the Major Histocompatibility Complex (MHC) loci is maintained over evolutionary time due to heterozygote advantage or frequency-dependent selection imposed by infectious pathogens.

105

Publications

8.4K

Citations

438

Authors

244

Institutions

Publications per year

2017–2026

17

Parents

Publications

105

The Shaping of Modern Human Immune Systems by Multiregional Admixture with Archaic Humans

Laurent Abi‐Rached, Matthew J. Jobin, Subhash Kulkarni et al. · Science · 2011 · 560 citations · Full text

, , +17

PERSPECTIVE: DETECTING ADAPTIVE MOLECULAR POLYMORPHISM: LESSONS FROM THE MHC

Daniel Garrigan, Philip W. Hedrick · Evolution · 2003 · 475 citations

, , +15

High MHC diversity maintained by balancing selection in an otherwise genetically monomorphic mammal

Andres Aguilar, Gary W. Roemer, S. L. Debenham et al. · Proceedings of the National Academy of Sciences · 2004 · 448 citations · Full text

, , +13

Multiple parasites are driving major histocompatibility complex polymorphism in the wild

K. Mathias Wegner, Thorsten B. H. Reusch, Martin Kalbe · Journal of Evolutionary Biology · 2003 · 341 citations · Full text

, , +17

Rapid and adaptive evolution of MHC genes under parasite selection in experimental vertebrate populations

Christophe Eizaguirre, Tobias L. Lenz, Martin Kalbe et al. · Nature Communications · 2012 · 320 citations · Full text

, , +17

1–5 of 105

Authors

438

  1. TL
    Tobias L. Lenz

    Max Planck Institute for Evolutionary Biology, Germany

    7 publications · 908 citations

    7

    h-index

  2. PW
    Philip W. Hedrick

    Arizona State University, United States

    5 publications · 1K citations

    5

    h-index

  3. CV
    Cock van Oosterhout

    University of East Anglia, United Kingdom

    5 publications · 493 citations

    5

    h-index

  4. JR
    Jacek Radwan

    Jagiellonian University, Poland

    5 publications · 188 citations

    5

    h-index

  5. SS
    Simone Sommer

    Universität Ulm, Germany

    5 publications · 294 citations

    5

    h-index

1–5 of 438

Institutions

244

  1. Max Planck Institute for Evolutionary Biology

    Plön, Germany

    8 h-index

    16 publications

    3K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    7 h-index

    12 publications

    533 citations

  3. Jagiellonian University

    Krakow, Poland

    5 h-index

    6 publications

    203 citations

  4. Lund University

    Lund, Sweden

    5 h-index

    11 publications

    1.1K citations

  5. University of the West Indies

    Saint Augustine, Trinidad and Tobago

    4 h-index

    6 publications

    614 citations

  6. University of Liverpool

    Liverpool, United Kingdom

    4 h-index

    7 publications

    946 citations

  7. Uppsala University

    Uppsala, Sweden

    4 h-index

    9 publications

    466 citations

  8. Western University

    London, Canada

    4 h-index

    9 publications

    233 citations

1–8 of 244

Venues

  1. Molecular Ecology

    11 publications · 518 citations

    11

    h-index

  2. Journal of Evolutionary Biology

    JEB · 8 publications · 765 citations

    8

    h-index

  3. Evolution

    7 publications · 1K citations

    7

    h-index

  4. Immunogenetics

    5 publications · 174 citations

    5

    h-index

  5. Molecular Biology and Evolution

    MBE · 5 publications · 517 citations

    5

    h-index

1–5