Concepedia

Method Ruggedness Assessment

Method Ruggedness Assessment is a methodological evaluation procedure that systematically examines the robustness of an analytical method by identifying and quantifying the effects of small, deliberate variations in experimental conditions on method performance, thereby distinguishing it from broader validation steps through its focused interrogation of operational tolerance and reproducibility.

22

Publications

1.4K

Citations

66

Authors

18

Institutions

Publications per year

2017–2026

1

Variants

Ruggedness

Parents

Publications

22

Guidance for robustness/ruggedness tests in method validation

Yvan Vander Heyden, Arend Nijhuis, J. Smeyers–Verbeke et al. · Journal of Pharmaceutical and Biomedical Analysis · 2001 · 630 citations

, , +9

Ruggedness tests for a high-performance liquid Chromatographic assay: Comparison of an evaluation at two and three levels by using two-level Plackett-Burman designs

Yvan Vander Heyden, C. Hartmann, D.L. Massart et al. · Analytica Chimica Acta · 1995 · 75 citations

, , +12

Ruggedness testing in analytical chemistry

M. Mulholland · TrAC Trends in Analytical Chemistry · 1988 · 69 citations

, , +11

RES, an expert system for the set-up and interpretation of a ruggedness test in HPLC method validation

J. van Leeuwen, L.M.C. Buydens, B.G.M. Vandeginste et al. · Chemometrics and Intelligent Laboratory Systems · 1991 · 69 citations · Full text

, , +7

Investigation of the limitations of saturated fractional factorial experimental designs, with confounding effects for an HPLC ruggedness test

M. Mulholland, J. Waterhouse · Chromatographia · 1988 · 56 citations

, , +7

1–5 of 22

Authors

66

  1. MM
    M. Mulholland

    Philips (United Kingdom), United Kingdom

    6 publications · 255 citations

    6

    h-index

  2. BV
    B.G.M. Vandeginste

    Radboud University Nijmegen, Netherlands

    5 publications · 798 citations

    5

    h-index

  3. YV
    Yvan Vander Heyden

    Vrije Universiteit Brussel, Belgium

    5 publications · 822 citations

    5

    h-index

  4. GK
    G. Kateman

    Radboud University Nijmegen, Netherlands

    3 publications · 115 citations

    3

    h-index

  5. JV
    J. van Leeuwen

    University of South Australia, Australia

    3 publications · 115 citations

    3

    h-index

1–5 of 66

Institutions

18

  1. Philips (United Kingdom)

    Farnborough, United Kingdom

    6 h-index

    23 publications

    807 citations

  2. Vrije Universiteit Brussel

    Brussels, Belgium

    5 h-index

    13 publications

    2.4K citations

  3. Radboud University Nijmegen

    Nijmegen, The Netherlands

    3 h-index

    20 publications

    706 citations

  4. Unilever (Netherlands)

    Rotterdam, Netherlands

    2 h-index

    6 publications

    1.5K citations

  5. University of Hertfordshire

    Hatfield, United Kingdom

    2 h-index

    5 publications

    116 citations

  6. Holst Centre (Netherlands)

    Eindhoven, Netherlands

    2 h-index

    7 publications

    442 citations

  7. Philips (United States)

    Andover, United States

    2 h-index

    5 publications

    129 citations

  8. Philips (Netherlands)

    Amsterdam, The Netherlands

    2 h-index

    7 publications

    442 citations

1–8 of 18

Venues

  1. Analytica Chimica Acta

    5 publications · 223 citations

    5

    h-index

  2. 4

    h-index

  3. 2

    h-index

  4. Journal of AOAC International

    2 publications · 41 citations

    2

    h-index

  5. Journal of Chromatography B

    1 publications · 50 citations

    1

    h-index

1–5