Concepedia

Memory Exhaustion

Memory Exhaustion is a state of impaired immune function characterized by the progressive loss of effector capabilities and proliferative potential in antigen-specific memory T cells, resulting from prolonged antigenic stimulation or chronic inflammation.

21

Publications

2.3K

Citations

150

Authors

52

Institutions

Publications per year

2017–2026

9

Variants

T Cell Exhaustion

Parents

Publications

21

Network Analysis Reveals Centrally Connected Genes and Pathways Involved in CD8+ T Cell Exhaustion versus Memory

Travis A. Doering, Alison Crawford, Jill Angelosanto et al. · Immunity · 2012 · 544 citations · Full text

, , +14

Progressive Loss of Memory T Cell Potential and Commitment to Exhaustion during Chronic Viral Infection

Jill Angelosanto, Shawn D. Blackburn, Alison Crawford et al. · Journal of Virology · 2012 · 278 citations · Full text

, , +17

Severely ill patients with COVID-19 display impaired exhaustion features in SARS-CoV-2–reactive CD8 <sup>+</sup> T cells

Anthony Kusnadi, Ciro Ramírez-Suástegui, Vicente Fajardo et al. · Science Immunology · 2021 · 249 citations · Full text

, , +17

Epigenetic scarring of exhausted T cells hinders memory differentiation upon eliminating chronic antigenic stimulation

Mohamed S. Abdel-Hakeem, Sasikanth Manne, Jean‐Christophe Beltra et al. · Nature Immunology · 2021 · 243 citations · Full text

, , +14

Bone marrow central memory and memory stem T-cell exhaustion in AML patients relapsing after HSCT

Maddalena Noviello, Francesco Manfredi, Eliana Ruggiero et al. · Nature Communications · 2019 · 186 citations · Full text

, , +17

1–5 of 21

Authors

150

  1. EJ
    E. John Wherry

    University of Pennsylvania, United States

    2 publications · 521 citations

    2

    h-index

  2. JB
    Jean‐Christophe Beltra

    University of Pennsylvania, United States

    2 publications · 309 citations

    2

    h-index

  3. JA
    Jill Angelosanto

    University of Pennsylvania, United States

    2 publications · 822 citations

    2

    h-index

  4. AC
    Alison Crawford

    University of Pennsylvania, United States

    2 publications · 822 citations

    2

    h-index

  5. JK
    Julia K. Polansky

    German Rheumatism Research Centre, Germany

    1 publications · 112 citations

    1

    h-index

1–5 of 150

Institutions

52

  1. University of Pennsylvania

    Philadelphia, United States

    3 h-index

    3 publications

    1.1K citations

  2. University of Miami

    Coral Gables, United States

    2 h-index

    2 publications

    404 citations

  3. Institut National de la Recherche Scientifique

    Québec, Canada

    1 h-index

    1 publications

    66 citations

  4. German Rheumatism Research Centre

    Berlin, Germany

    1 h-index

    1 publications

    112 citations

  5. Vita-Salute San Raffaele University

    Milan, Italy

    1 h-index

    1 publications

    186 citations

  6. Clatterbridge Cancer Centre NHS Foundation Trust

    Bebington, United Kingdom

    1 h-index

    1 publications

    249 citations

  7. Charité - Universitätsmedizin Berlin

    Berlin, Germany

    1 h-index

    1 publications

    112 citations

  8. Translational Therapeutics (United States)

    Arlington, United States

    1 h-index

    1 publications

    243 citations

1–8 of 52

Venues

  1. Nature Communications

    2 publications · 298 citations

    2

    h-index

  2. AIDS

    1 publications · 25 citations

    1

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 1 publications · 66 citations

    1

    h-index

  4. Current HIV Research

    1 publications · 36 citations

    1

    h-index

  5. Immunity

    1 publications · 544 citations

    1

    h-index

1–5