Concepedia

Mediator Phosphorylation

Mediator Phosphorylation is a post-translational modification process in which specific subunits of the Mediator complex are phosphorylated, thereby differentially regulating its structural conformation and functional interactions with RNA polymerase II and transcription factors to modulate gene transcription.

92

Publications

5.6K

Citations

618

Authors

213

Institutions

Publications per year

2017–2026

25

Parents

Publications

92

Specific Activation of Smad1 Signaling Pathways by the BMP7 Type I Receptor, ALK2

Marina Macías‐Silva, Pamela A. Hoodless, Shao Jun Tang et al. · Journal of Biological Chemistry · 1998 · 476 citations · Full text

, , +17

Phosphorylation of Ser465 and Ser467 in the C Terminus of Smad2 Mediates Interaction with Smad4 and Is Required for Transforming Growth Factor-β Signaling

Serhiy Souchelnytskyi, Kiyoshi Tamaki, Ulla Engström et al. · Journal of Biological Chemistry · 1997 · 389 citations · Full text

, , +14

Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways

Yi Jiang, Philippe Veschambre, Hediye Erdjument‐Bromage et al. · Proceedings of the National Academy of Sciences · 1998 · 304 citations

, , +17

TFIIH Phosphorylation of the Pol II CTD Stimulates Mediator Dissociation from the Preinitiation Complex and Promoter Escape

Koon Ho Wong, Yi Jin, Kevin Struhl · Molecular Cell · 2014 · 218 citations · Full text

, , +14

Structures of the human Mediator and Mediator-bound preinitiation complex

Xizi Chen, Xiaotong Yin, Jiabei Li et al. · Science · 2021 · 183 citations

, , +17

1–5 of 92

Authors

618

  1. PT
    Peter ten Dijke

    Leiden University Medical Center, Netherlands

    3 publications · 421 citations

    3

    h-index

  2. HE
    Henry E. Pelish

    Harvard University, United States

    2 publications · 214 citations

    2

    h-index

  3. SP
    Sven Perner

    Research Center Borstel - Leibniz Lung Center, Germany

    2 publications · 73 citations

    2

    h-index

  4. RD
    Roger D. Kornberg

    Stanford University, United States

    2 publications · 425 citations

    2

    h-index

  5. HC
    H. Chua

    Hong Kong Polytechnic University, Hong Kong SAR China

    2 publications · 69 citations

    2

    h-index

1–5 of 618

Institutions

213

  1. Northwestern University

    Evanston, United States

    5 h-index

    22 publications

    1.6K citations

  2. Harvard University

    Cambridge, United States

    4 h-index

    12 publications

    1.6K citations

  3. Centre National de la Recherche Scientifique

    Paris, France

    3 h-index

    19 publications

    894 citations

  4. Leiden University Medical Center

    Leiden, The Netherlands

    3 h-index

    3 publications

    61 citations

  5. The University of Texas at San Antonio Health Science Center

    San Antonio, United States

    3 h-index

    7 publications

    147 citations

  6. Memorial Sloan Kettering Cancer Center

    New York, United States

    3 h-index

    12 publications

    2.4K citations

  7. The University of Texas MD Anderson Cancer Center

    Houston, United States

    3 h-index

    14 publications

    785 citations

  8. Chang Gung Memorial Hospital

    Taipei, Taiwan

    3 h-index

    10 publications

    164 citations

1–8 of 213

Venues

  1. Journal of Biological Chemistry

    JBC · 9 publications · 1.3K citations

    9

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 4 publications · 511 citations

    4

    h-index

  3. Molecular Cell

    4 publications · 399 citations

    4

    h-index

  4. Nucleic Acids Research

    3 publications · 51 citations

    3

    h-index

  5. Journal of Cellular Physiology

    3 publications · 91 citations

    3

    h-index

1–5