Concepedia

Mediator Function In Gene Repression

Mediator Function in Gene Repression is a molecular regulatory mechanism within the Mediator complex that facilitates gene repression by serving as a transcriptional co-repressor module through targeted interactions with repressive transcription factors and chromatin-modifying enzymes to attenuate RNA polymerase II-mediated transcription initiation.

72

Publications

9.5K

Citations

403

Authors

139

Institutions

Publications per year

2017–2026

10

Parents

Publications

72

Mediator and cohesin connect gene expression and chromatin architecture

Michael H. Kagey, Jamie J. Newman, Steve Bilodeau et al. · Nature · 2010 · 1.9K citations · Full text

, , +14

KAP-1, a novel corepressor for the highly conserved KRAB repression domain.

Joshua R. Friedman, William J. Fredericks, D. E. Jensen et al. · Genes & Development · 1996 · 675 citations · Full text

, , +16

The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors

Jeroen P. Roose, Miranda Molenaar, Josi Peterson et al. · Nature · 1998 · 670 citations

, , +14

Mad-max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3

Donald E. Ayer, Quentin Lawrence, Robert N. Eisenman · Cell · 1995 · 589 citations · Full text

, , +15

The human CDK8 subcomplex is a molecular switch that controls Mediator coactivator function

Matthew T. Knuesel, Krista Meyer, Carrie Bernecky et al. · Genes & Development · 2009 · 348 citations · Full text

, , +16

1–5 of 72

Authors

403

  1. FC
    Frank C. P. Holstege

    University Medical Center Utrecht, Netherlands

    3 publications · 341 citations

    3

    h-index

  2. RS
    R. Steven Conlan

    Swansea University, United Kingdom

    3 publications · 285 citations

    3

    h-index

  3. AK
    Amy K. Walker

    Harvard University, United States

    2 publications · 56 citations

    2

    h-index

  4. SB
    Stefan Björklund

    Umeå University, Sweden

    2 publications · 291 citations

    2

    h-index

  5. DJ
    Dylan J. Taatjes

    University of Colorado Boulder, United States

    2 publications · 2.3K citations

    2

    h-index

1–5 of 403

Institutions

139

  1. Harvard University

    Cambridge, United States

    3 h-index

    7 publications

    736 citations

  2. Stanford University

    Stanford, United States

    3 h-index

    16 publications

    3.9K citations

  3. Howard Hughes Medical Institute

    Chevy Chase, United States

    3 h-index

    4 publications

    546 citations

  4. Chinese Academy of Sciences

    Beijing, China

    3 h-index

    20 publications

    2.4K citations

  5. Institute of Genetics and Developmental Biology

    Beijing, China

    3 h-index

    20 publications

    2.4K citations

  6. University Medical Center Utrecht

    Utrecht, The Netherlands

    3 h-index

    10 publications

    1.5K citations

  7. Rockefeller University

    New York, United States

    3 h-index

    10 publications

    928 citations

  8. Columbia University

    New York, United States

    2 h-index

    7 publications

    552 citations

1–8 of 139

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 7 publications · 699 citations

    7

    h-index

  2. Journal of Biological Chemistry

    JBC · 7 publications · 479 citations

    7

    h-index

  3. Molecular Cell

    6 publications · 873 citations

    6

    h-index

  4. Biochemical and Biophysical Research Communications

    BBRC · 6 publications · 165 citations

    6

    h-index

  5. Oncogene

    5 publications · 459 citations

    5

    h-index

1–5