Concepedia

Mechanistic Absorption Modeling

Mechanistic Absorption Modeling is a computational modeling approach within physiologically based pharmacokinetic modeling that specifically describes the processes of drug transit and dissolution in the gastrointestinal tract through biophysical and biochemical principles, distinguishing it from empirical or compartmental absorption models by its reliance on first-order physiological mechanisms.

126

Publications

6K

Citations

485

Authors

175

Institutions

Publications per year

2017–2026

34

Parents

Publications

126

Intestinal absorption and biomagnification of organic contaminants in fish, wildlife, and humans

Barry C. Kelly, Frank A. P. C. Gobas, Michael S. McLachlan · Environmental Toxicology and Chemistry · 2004 · 232 citations

, , +17

Quantitative mechanistic studies in simultaneous fluid flow and intestinal absorption using steroids as model solutes

Ichiro Komiya, J.Y. Park, A. Kamani et al. · International Journal of Pharmaceutics · 1980 · 228 citations · Full text

, , +17

Intestinal Drug Absorption and Metabolism I: Comparison of Methods and Models to Study Physiological Factors of In Vitro and In Vivo Intestinal Absorption

William H. Barr, Sidney Riegelman · Journal of Pharmaceutical Sciences · 1970 · 190 citations

, , +16

In silico predictions of gastrointestinal drug absorption in pharmaceutical product development: Application of the mechanistic absorption model GI-Sim

Erik Sjögren, Jan Westergren, Iain Grant et al. · European Journal of Pharmaceutical Sciences · 2013 · 167 citations

, , +16

Prediction of human absorption of natural compounds by the non-everted rat intestinal sac model

Liping Ruan, S. Chen, Bin Yu et al. · European Journal of Medicinal Chemistry · 2006 · 155 citations

, , +16

1–5 of 126

Authors

485

  1. FK
    Filippos Kesisoglou

    Merck & Co., Inc., Rahway, NJ, USA (United States), United States

    12 publications · 523 citations

    11

    h-index

  2. NF
    Norman F.H. Ho

    University of Michigan, United States

    9 publications · 643 citations

    9

    h-index

  3. WI
    William I. Higuchi

    University of Utah, United States

    7 publications · 569 citations

    7

    h-index

  4. MJ
    Masoud Jamei

    Simcyp (United Kingdom), United Kingdom

    6 publications · 266 citations

    6

    h-index

  5. HL
    Hans Lennernäs

    Uppsala University, Sweden

    4 publications · 358 citations

    4

    h-index

1–5 of 485

Institutions

175

  1. University of Michigan

    Ann Arbor, United States

    12 h-index

    40 publications

    3.2K citations

  2. Merck & Co., Inc., Rahway, NJ, USA (United States)

    Rahway, United States

    10 h-index

    19 publications

    773 citations

  3. Uppsala University

    Uppsala, Sweden

    8 h-index

    19 publications

    1.1K citations

  4. Simcyp (United Kingdom)

    Sheffield, United Kingdom

    6 h-index

    19 publications

    884 citations

  5. Simulations Plus (United States)

    Lancaster, United States

    5 h-index

    8 publications

    308 citations

  6. United States Military Academy

    West Point, United States

    5 h-index

    5 publications

    171 citations

  7. Roche (Switzerland)

    Basel, Switzerland

    5 h-index

    22 publications

    1K citations

  8. Goethe University Frankfurt

    Frankfurt am Main, Germany

    5 h-index

    11 publications

    587 citations

1–8 of 175

Venues

  1. Journal of Pharmaceutical Sciences

    15 publications · 687 citations

    12

    h-index

  2. The AAPS Journal

    AAPSJ · 12 publications · 635 citations

    12

    h-index

  3. Pharmaceutical Research

    11 publications · 665 citations

    11

    h-index

  4. Molecular Pharmaceutics

    9 publications · 375 citations

    9

    h-index

  5. European Journal of Pharmaceutical Sciences

    8 publications · 500 citations

    8

    h-index

1–5