Concepedia

Mechanism-based Toxicity

Mechanism-Based Toxicity is a toxicological phenomenon characterized by the induction of tissue damage or cellular dysfunction through specific, identifiable biochemical interactions between a toxicant and its molecular target, distinguished from incidental or nonspecific toxicity by its dependency on defined mechanisms of action.

200

Publications

9.4K

Citations

1.3K

Authors

406

Institutions

Publications per year

2017–2026

98

Variants

Mechanism-based Toxicities

Parents

Publications

200

A general mechanism for intracellular toxicity of metal-containing nanoparticles

Stefania Sabella, Randy P. Carney, Virgilio Brunetti et al. · Nanoscale · 2014 · 458 citations · Full text

, , +17

Toxicity of zinc oxide nanoparticles to zebrafish embryo: a physicochemical study of toxicity mechanism

Wei Bai, Zhiyong Zhang, Wenjing Tian et al. · Journal of Nanoparticle Research · 2009 · 404 citations

, , +15

Negligible particle-specific toxicity mechanism of silver nanoparticles: The role of Ag+ ion release in the cytosol

Valeria De Matteis, Maria Ada Malvindi, Antonio Galeone et al. · Nanomedicine Nanotechnology Biology and Medicine · 2014 · 277 citations

, , +16

Role of inducible cyclooxygenase (COX-2) in inflammation.

Karen Seibert, Jaime L. Masferrer · PubMed · 1994 · 275 citations

, , +14

Phase I and Pharmacologic Study of SNS-032, a Potent and Selective Cdk2, 7, and 9 Inhibitor, in Patients With Advanced Chronic Lymphocytic Leukemia and Multiple Myeloma

Wei-Gang Tong, Rong Chen, William Plunkett et al. · Journal of Clinical Oncology · 2010 · 218 citations

, , +17

1–5 of 200

Authors

1.3K

  1. HX
    Hanhong Xu

    South China Agricultural University, China

    3 publications · 113 citations

    3

    h-index

  2. ZY
    Zhibin Yin

    Xiamen University, China

    3 publications · 113 citations

    3

    h-index

  3. CL
    Chuanxin Liu

    Jining Medical University, China

    3 publications · 77 citations

    3

    h-index

  4. MD
    Mingyi Du

    South China Agricultural University, China

    3 publications · 113 citations

    3

    h-index

  5. ZC
    Zongwei Cai

    Hong Kong Baptist University, Hong Kong SAR China

    3 publications · 106 citations

    3

    h-index

1–5 of 1.3K

Institutions

406

  1. Chinese Academy of Sciences

    Beijing, China

    9 h-index

    43 publications

    3.5K citations

  2. South China Agricultural University

    Guangzhou, China

    8 h-index

    49 publications

    1.4K citations

  3. State Key Laboratory of Pollution Control and Resource Reuse

    Nanjing, China

    7 h-index

    21 publications

    1K citations

  4. Nankai University

    Tianjin, China

    5 h-index

    20 publications

    610 citations

  5. Tongji University

    Shanghai, China

    4 h-index

    23 publications

    1.1K citations

  6. Northeast Agricultural University

    Harbin, China

    4 h-index

    28 publications

    835 citations

  7. Harvard University

    Cambridge, United States

    4 h-index

    16 publications

    910 citations

  8. Hong Kong Baptist University

    Hong Kong, Hong Kong

    4 h-index

    14 publications

    448 citations

1–8 of 406

Venues

  1. Ecotoxicology and Environmental Safety

    EES · 14 publications · 516 citations

    13

    h-index

  2. Toxins

    6 publications · 124 citations

    6

    h-index

  3. The Science of The Total Environment

    6 publications · 287 citations

    6

    h-index

  4. International Journal of Molecular Sciences

    IJMS · 6 publications · 154 citations

    6

    h-index

  5. Journal of Agricultural and Food Chemistry

    5 publications · 137 citations

    5

    h-index

1–5