Concepedia

Mechanical Unfolding Pathways

Mechanical Unfolding Pathways is a theoretical construct in single-molecule force spectroscopy that delineates the sequence of conformational transitions a biomolecule undergoes when subjected to mechanical perturbation, distinguishing itself from equilibrium unfolding mechanisms by characterizing pathway dependence under non-equilibrium tensile conditions.

403

Publications

29.3K

Citations

1.2K

Authors

481

Institutions

Publications per year

2017–2026

90

Parents

Publications

403

Reversible Unfolding of Individual Titin Immunoglobulin Domains by AFM

Matthias Rief, Mathias Gautel, Filipp Oesterhelt et al. · Science · 1997 · 3.1K citations

, , +17

Mechanical and chemical unfolding of a single protein: A comparison

Mariano Carrión‐Vázquez, Andrés F. Oberhauser, Susan A. Fowler et al. · Proceedings of the National Academy of Sciences · 1999 · 1K citations

, , +17

Mechanical unfolding intermediates in titin modules

Piotr E. Marszałek, Hui Lü, Hongbin Li et al. · Nature · 1999 · 808 citations

, , +12

Elasticity and unfolding of single molecules of the giant muscle protein titin

Larissa Tskhovrebova, John Trinick, John Sleep et al. · Nature · 1997 · 745 citations

, , +14

Unfolding Pathways of Individual Bacteriorhodopsins

Filipp Oesterhelt, Dieter Oesterhelt, Matthias Pfeiffer et al. · Science · 2000 · 688 citations

, , +17

1–5 of 403

Authors

1.2K

  1. HL
    Hongbin Li

    University of British Columbia, Canada

    23 publications · 1.6K citations

    18

    h-index

  2. MR
    Matthias Rief

    Technical University of Munich, Germany

    16 publications · 5.1K citations

    13

    h-index

  3. JM
    Julio M. Fernández

    Columbia University, United States

    12 publications · 6.3K citations

    12

    h-index

  4. AF
    Andrés F. Oberhauser

    The University of Texas Medical Branch at Galveston, United States

    12 publications · 2.8K citations

    12

    h-index

  5. HE
    Hermann E. Gaub

    Ludwig-Maximilians-Universität München, Germany

    13 publications · 5K citations

    12

    h-index

1–5 of 1.2K

Institutions

481

  1. University of British Columbia

    Vancouver, Canada

    18 h-index

    74 publications

    2.8K citations

  2. Ludwig-Maximilians-Universität München

    Munich, Germany

    15 h-index

    57 publications

    7K citations

  3. University of Cambridge

    Cambridge, United Kingdom

    14 h-index

    48 publications

    10.9K citations

  4. University of Illinois Urbana-Champaign

    Urbana, United States

    14 h-index

    35 publications

    5.1K citations

  5. University of California, Berkeley

    Berkeley, United States

    14 h-index

    38 publications

    5.6K citations

  6. University of Leeds

    Leeds, United Kingdom

    13 h-index

    38 publications

    2K citations

  7. Massachusetts Institute of Technology

    Cambridge, United States

    12 h-index

    28 publications

    2.3K citations

  8. Polish Academy of Sciences

    Warsaw, Poland

    12 h-index

    18 publications

    802 citations

1–8 of 481

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 36 publications · 5K citations

    33

    h-index

  2. Biophysical Journal

    48 publications · 2.4K citations

    31

    h-index

  3. Journal of the American Chemical Society

    JACS · 21 publications · 1.3K citations

    21

    h-index

  4. The Journal of Chemical Physics

    16 publications · 686 citations

    15

    h-index

  5. Journal of Molecular Biology

    JMB · 14 publications · 1.9K citations

    14

    h-index

1–5