Concepedia

Mcm Complex Activation

MCM Complex Activation is a molecular mechanism in DNA replication initiation that refers to the regulated recruitment and conversion of the inactive MCM2-7 hexameric helicase complex into an active, bidirectional replicative helicase at origins of replication through phosphorylation by kinases and association with cofactors such as Cdc45 and GINS.

169

Publications

16.3K

Citations

747

Authors

256

Institutions

Publications per year

2017–2026

37

Parents

Publications

169

GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks

Agnieszka Gambus, Richard C. Jones, Alberto Sánchez‐Díaz et al. · Nature Cell Biology · 2006 · 766 citations

, , +14

Components and Dynamics of DNA Replication Complexes in S. cerevisiae: Redistribution of MCM Proteins and Cdc45p during S Phase

Oscar M. Aparicio, Deborah M Weinstein, Stephen P. Bell · Cell · 1997 · 736 citations · Full text

, , +16

Concerted Loading of Mcm2–7 Double Hexamers around DNA during DNA Replication Origin Licensing

Dirk Remus, Fabienne Beuron, Gökhan Tolun et al. · Cell · 2009 · 685 citations · Full text

, , +11

Activation of the MCM2-7 Helicase by Association with Cdc45 and GINS Proteins

Ivar Ilves, Tatjana Petojevic, James J. Pesavento et al. · Molecular Cell · 2010 · 546 citations · Full text

, , +5

Cdc7-Dbf4 Phosphorylates MCM Proteins via a Docking Site-Mediated Mechanism to Promote S Phase Progression

Yi-Jun Sheu, Bruce Stillman · Molecular Cell · 2006 · 342 citations · Full text

, , +13

1–5 of 169

Authors

747

  1. SP
    Stephen P. Bell

    Massachusetts Institute of Technology, United States

    12 publications · 2.3K citations

    12

    h-index

  2. CS
    Christian Speck

    Imperial College London, United Kingdom

    6 publications · 431 citations

    6

    h-index

  3. YI
    Yukio Ishimi

    Mitsubishi Group (Japan), Japan

    6 publications · 306 citations

    6

    h-index

  4. JC
    Johannes C. Walter

    Harvard University, United States

    5 publications · 974 citations

    5

    h-index

  5. YI
    Yoshizumi Ishino

    Kyushu University, Japan

    5 publications · 173 citations

    5

    h-index

1–5 of 747

Institutions

256

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    16 h-index

    51 publications

    6.9K citations

  2. Massachusetts Institute of Technology

    Cambridge, United States

    12 h-index

    45 publications

    8.1K citations

  3. The University of Osaka

    Osaka, Japan

    8 h-index

    24 publications

    1.6K citations

  4. Tokyo Metropolitan Institute of Medical Science

    Tokyo, Japan

    6 h-index

    22 publications

    2.3K citations

  5. Imperial College London

    London, United Kingdom

    6 h-index

    29 publications

    1.5K citations

  6. Kyushu University

    Fukuoka, Japan

    6 h-index

    25 publications

    941 citations

  7. The Francis Crick Institute

    London, United Kingdom

    5 h-index

    26 publications

    2.1K citations

  8. Van Andel Institute

    Grand Rapids, United States

    5 h-index

    14 publications

    1.6K citations

1–8 of 256

Venues

  1. Journal of Biological Chemistry

    JBC · 24 publications · 2K citations

    23

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  2. Molecular Cell

    13 publications · 2.5K citations

    13

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  3. The EMBO Journal

    11 publications · 1.6K citations

    11

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 12 publications · 753 citations

    11

    h-index

  5. Nucleic Acids Research

    9 publications · 233 citations

    9

    h-index

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