Concepedia

Maximum Tolerated Dose Extrapolation

Maximum Tolerated Dose Extrapolation is a dose-response assessment method that identifies the highest dose of a substance expected to be tolerable in humans by extending findings from non-human studies through pharmacokinetic and pharmacodynamic modeling.

14

Publications

503

Citations

54

Authors

21

Institutions

Publications per year

2017–2026

1

Parents

Publications

14

Interspecific Scaling of Toxicity Data

Curtis C. Travis, R.K. White · Risk Analysis · 1988 · 110 citations

, , +16

Benefits of the maximum tolerated dose (MTD) and maximum tolerated concentration (MTC) concept in aquatic toxicology

Thomas H. Hutchinson, Christian Bögi, Matthew J. Winter et al. · Aquatic Toxicology · 2008 · 62 citations

, , +16

Quick Estimate of the Regulatory Virtually Safe Dose Based on the Maximum Tolerated Dose for Rodent Bioassays

David W. Gaylor, L S Gold · Regulatory Toxicology and Pharmacology · 1995 · 57 citations

, , +14

Preclinical evaluation of the anticancer activity and toxicity of 9-nitro-20(S)-camptothecin (Rubitecan)

Beppino C. Giovanella, John S. Stehlin, Hellmuth R. Hinz et al. · International Journal of Oncology · 2002 · 48 citations

, , +13

10% Body weight (gain) change as criterion for the maximum tolerated dose: A critical analysis

Damiën van Berlo, Marjolijn Woutersen, André Müller et al. · Regulatory Toxicology and Pharmacology · 2022 · 43 citations · Full text

, , +10

1–5 of 14

Authors

54

  1. DW
    David W. Gaylor

    National Center for Toxicological Research, United States

    3 publications · 111 citations

    3

    h-index

  2. LS
    L S Gold

    Lawrence Berkeley National Laboratory, United States

    1 publications · 57 citations

    1

    h-index

  3. ME
    Marja E.J. Pronk

    National Institute for Public Health and the Environment, Netherlands

    1 publications · 43 citations

    1

    h-index

  4. AO
    Azusa Okaniwa

    Tanabe Research Laboratories, United States

    1 publications · 26 citations

    1

    h-index

  5. CS
    Cristiana Sessa

    Ospedale San Giovanni Bellinzona, Switzerland

    1 publications · 11 citations

    1

    h-index

1–5 of 54

Institutions

21

  1. National Center for Toxicological Research

    Pine Bluff, United States

    3 h-index

    6 publications

    218 citations

  2. United States Food and Drug Administration

    Silver Spring, United States

    3 h-index

    6 publications

    218 citations

  3. Lawrence Berkeley National Laboratory

    Berkeley, United States

    2 h-index

    3 publications

    143 citations

  4. Institute of Oncology Research

    Bellinzona, Switzerland

    1 h-index

    2 publications

    22 citations

  5. Keio University

    Tokyo, Japan

    1 h-index

    2 publications

    38 citations

  6. Astellas Pharma (United Kingdom)

    London, United Kingdom

    1 h-index

    1 publications

    19 citations

  7. United States Department of Energy

    Washington, United States

    1 h-index

    2 publications

    220 citations

  8. Oak Ridge National Laboratory

    Oak Ridge, United States

    1 h-index

    1 publications

    110 citations

1–8 of 21

Venues

  1. Regulatory Toxicology and Pharmacology

    RTP · 3 publications · 129 citations

    3

    h-index

  2. Risk Analysis

    2 publications · 135 citations

    2

    h-index

  3. Investigational New Drugs

    1 publications · 19 citations

    1

    h-index

  4. International Journal of Oncology

    1 publications · 48 citations

    1

    h-index

  5. Aquatic Toxicology

    1 publications · 62 citations

    1

    h-index

1–5