Concepedia

Maximum Tolerated Concentration

Maximum Tolerated Concentration is the highest concentration of a therapeutic agent in the body that can be sustained without causing unacceptable or dose-limiting toxicity, serving as a critical pharmacokinetic threshold in drug development and dosing regimen design.

443

Publications

28.9K

Citations

3.1K

Authors

855

Institutions

Publications per year

2017–2026

67

Parents

Publications

443

Safety, Pharmacokinetic, and Antitumor Activity of SU11248, a Novel Oral Multitarget Tyrosine Kinase Inhibitor, in Patients With Cancer

Sandrine Faivre, Catherine Delbaldo, Karina Vera et al. · Journal of Clinical Oncology · 2005 · 1.2K citations · Full text

, , +17

Vitamin C Pharmacokinetics: Implications for Oral and Intravenous Use

Sebastian J. Padayatty, He Sun, Yaohui Wang et al. · Annals of Internal Medicine · 2004 · 967 citations

, , +11

A Phase I and Pharmacological Study with Imidazolium-<b> <i>trans-</i> </b>DMSO-imidazole-tetrachlororuthenate, a Novel Ruthenium Anticancer Agent

Jeany M. Rademaker-Lakhai, H.J.G.D. van den Bongard, Dick Pluim et al. · Clinical Cancer Research · 2004 · 823 citations · Full text

, , +12

Combretastatin A-4, an agent that displays potent and selective toxicity toward tumor vasculature.

G. Dark, S A Hill, Vivien E. Prise et al. · PubMed · 1997 · 624 citations

, , +13

Phase I Trial of Recombinant Immunotoxin Anti-Tac(Fv)-PE38 (LMB-2) in Patients With Hematologic Malignancies

Robert J. Kreitman, Wyndham H. Wilson, Jeffrey D. White et al. · Journal of Clinical Oncology · 2000 · 421 citations

, , +15

1–5 of 443

Authors

3.1K

  1. EK
    Eric K. Rowinsky

    The University of Texas at San Antonio Health Science Center, United States

    8 publications · 861 citations

    8

    h-index

  2. DD
    Daniel D. Von Hoff

    Translational Genomics Research Institute, United States

    8 publications · 681 citations

    8

    h-index

  3. HM
    Hironobu Minami

    National Cancer Center Hospital East, Japan

    6 publications · 179 citations

    6

    h-index

  4. IP
    Ira Pastan

    National Cancer Institute, United States

    5 publications · 583 citations

    5

    h-index

  5. MH
    Manuel Hidalgo

    Johns Hopkins University, United States

    5 publications · 181 citations

    5

    h-index

1–5 of 3.1K

Institutions

855

  1. National Cancer Institute

    Bethesda, United States

    19 h-index

    97 publications

    5K citations

  2. National Institutes of Health

    Bethesda, United States

    15 h-index

    65 publications

    3.1K citations

  3. The University of Texas MD Anderson Cancer Center

    Houston, United States

    11 h-index

    59 publications

    9.3K citations

  4. The University of Texas at San Antonio Health Science Center

    San Antonio, United States

    10 h-index

    94 publications

    9K citations

  5. National Cancer Center Hospital East

    Kashiwa, Japan

    10 h-index

    38 publications

    1.2K citations

  6. Institut Gustave Roussy

    Villejuif, France

    9 h-index

    45 publications

    16.7K citations

  7. Center for Cancer Research

    Bethesda, United States

    8 h-index

    31 publications

    1.2K citations

  8. Dana-Farber Cancer Institute

    Boston, United States

    7 h-index

    87 publications

    14.3K citations

1–8 of 855

Venues

  1. Journal of Clinical Oncology

    52 publications · 6.6K citations

    35

    h-index

  2. PubMed

    Repository · 51 publications · 2.7K citations

    26

    h-index

  3. Clinical Cancer Research

    20 publications · 2.9K citations

    20

    h-index

  4. Antimicrobial Agents and Chemotherapy

    AAC · 10 publications · 642 citations

    10

    h-index

  5. Cancer Research

    6 publications · 185 citations

    6

    h-index

1–5